Vegetables and fruits have an interesting nutritional profile, rich in bioactive metabolites, holding a high antioxidant potential health associated benefits. However, their functional properties, the shorter shelf-life due to high-water content, seasonality nature lead extensive food losses waste. The valorization of vegetables by-products through development value-added products application p...

Evidence that lesions of the basolateral amygdala complex (BLC) impair memory for fear conditioning in rats, measured by lack of "freezing" behavior in the presence of cues previously paired with footshocks, has suggested that the BLC may be a critical locus for the memory of fear conditioning. However, evidence that BLC lesions may impair unlearned as well as conditioned freezing makes it diff...

Signaled active avoidance (AA) paradigms train subjects to prevent an aversive outcome by performing a learned behavior during the presentation of a conditioned cue. This complex form of conditioning involves pavlovian and instrumental components, which produce competing behavioral responses that must be reconciled for the subject to successfully avoid an aversive stimulus. In signaled AA parad...

Numerous biopharmaceuticals are produced in recombinant microorganisms in the controlled environment of a bioreactor, a process known as Upstream Process. To minimize product loss due to physico-chemical and enzymatic degradation, the Upstream Process should be directly followed by product purification, known as Downstream Process. However, the Downstream Process can be technologically complex ...

Tunnels located in cold regions are vulnerable to frost damage resulting from the special atmosphere, which directly threatens safety of tunnel structure and operation. Frost problems tunnels have not been fundamentally resolved. This paper reviews design theory mitigation techniques currently used design, construction maintenance region tunnels. The depths freezing thawing heaving force key in...

Antifreeze glycoproteins (AFGPs) found in various fish are used by the organisms to prevent freezing. While these compounds have been studied for their ability bind to, and complete crystallization of water, exact mechanisms which AFGPs freezing still undetermined. Therefore, building upon our previous work, this study uses molecular dynamics simulations assess effects hydroxyl group separation...

Finally, there are fascinating biologic reasons to address this issue further. In essence, our understanding of the mechanism of action of tamoxifen and other hormonal agents is changing. Initial theories suggested these agent were cytostatic and essentially acted by "freezing" cells in the early G1 phase of the cell cycle. Thus, it was logical to hypothesize that it may be necessary to adminis...