Primary cutaneous lymphomas are extranodal non-Hodgkin of T- or B- cell origin, that predominantly affect older patients but have been reported in all age groups and as early the first years life. Diagnosis is challenging requires high clinical suspicion close collaboration between dermatologists, pediatric oncologists pathologists. Skin involvement children adolescents can either be primary se...

NK/T-cell lymphoma (NKTCL) is characterized by the expression of the NK-cell antigen CD56. Non-nasal NK/T-cell lymphomas are subdivided into primary cutaneous and 4 subtypes of secondary cutaneous lymphomas; nasal type, aggressive, blastic (blastoid), and other specific NK-like cell lymphoma. Aggressive NK/T-cell lymphoma/leukemia is a rare leukemic variant of nasal type NKTCL. We herein report...

Malignant lymphomas that secondarily involve the skin are relatively common and may be difficult to distinguish from primary skin lymphomas. While the morphologic features of primary and secondary lymphomas of the skin are often very similar, the clinical behavior of primary and secondary disease is often dramatically different. Although large series of secondary cutaneous lymphomas are uncommo...

INTRODUCTION Cytotoxic CD8+ T-cell lymphomas are only rarely encountered and thus remain only poorly characterized. Our aim was to collect and correlate clinical and histological data of CD8+ skin lymphoma infiltrates to obtain a proper subtype assignment of CD8+ skin lymphoma infiltrates and to derive putative prognostic markers thereof. METHODS Formalin-fixed and paraffin-embedded (FFPE) ti...

BACKGROUND Peripheral nodal follicular T-cell lymphomas expressing follicular helper T-cell (T(FH)) markers have recently been identified. Such lymphomas are characterized by a nodal neoplastic T-cell proliferation accompanied by numerous reactive B cells and demonstrate some overlap with nodal angioimmunoblastic T-cell lymphoma (AITL). We identified 5 cases of cutaneous T-cell lymphoma with a ...

Pagetoid reticulosis (PR) is a low-grade primary cutaneous T-cell lymphoma that usually presents as a solitary, slowly enlarging erythematous or hyperkeratotic plaque on the distal areas of the extremities. Histopathologically, it is characterized by a dense, band-like infiltrate of atypical lymphocytes with prominent epidermotropism within a hyperplastic epidermis, and immunophenotypic studies...