Homocystinuria follows an autosomal recessive pattern and transpires due to Cystathionine beta-synthase enzyme deficiency. This condition is associated with thrombotic thromboembolic complications increase in homocysteine methionine levels the plasma urine. We present a case of Indian adolescent boy who presented us generalized tonic clinic seizure Broca's aphasia he was diagnosed as having hom...

When studying the role of the locus coeruleus (LC) in the regulation of seizure susceptibility in rats, we found that bilateral LC lesion significantly lowered the electroshock seizure threshold for the tonic extension of forelegs. The pattern of maximal electroshock seizure was not affected by LC lesion, although the recovery time was slightly prolonged. In the pentylenetetrazol (PTZ) seizure ...

BACKGROUND Seizure as the initial manifestation of aortic dissection is rare. CASE REPORT An 88-year-old female experienced a first generalized tonic clonic seizure, which was terminated with midazolam. Acute cerebral magnetic resonance imaging and angiography were non-informative. After awaking she complained about cramping pain in the right upper extremity, which was accompanied by involunt...

CASE REPORT A 48-year-old man with mild mental retardation was brought to the emergency department having had a seizure. He was taking lamotrigine, carbamazepine and phenytoin for generalized tonic-clonic seizures and absence-like spells since childhood. Previous EEG showed normal background (FigureA) with widespread photoparoxysmal activity, which suggested the diagnosis of probable generalize...

OBJECTIVE The purpose of this article is to review the use of serum prolactin assay in epileptic seizure diagnosis. METHODS The authors identified relevant studies in multiple databases and reference lists. Studies that met inclusion criteria were summarized and rated for quality of evidence, and the results were analyzed and pooled where appropriate. RESULTS Most studies used a serum prola...

Changes in seizure type of severe myoclonic epilepsy (SME) in infancy were reviewed retrospectively in 14 patients (11 males and 3 females) who were followed-up to the age of 7 years or more. The observation period ranged from 5 to 16 years with a mean of 10 years. During the follow-up, three or four types of seizures were seen per patient, but the pattern of appearance and disappearance of eac...

Cardiac rhythm abnormalities in the context of epilepsy are a well-known phenomenon. However, they are under-recognized and often missed. The pathophysiology of these events is unclear. Bradycardia and asystole are preceded by seizure onset suggesting ictal propagation into the cortex impacting cardiac autonomic function, and the insula and amygdala being possible culprits. Sudden unexpected de...