نتایج جستجو برای: proadrenomedullin n terminal 20 peptide

تعداد نتایج: 1704817  

Journal: :Journal of neuroendocrinology 2000
L M Montuenga M A Burrell M Garayoa D Llopiz M Vos T Moody D García-Ros A Martínez A C Villaro T Elsasser F Cuttitta

Expression of proadrenomedullin-derived peptides in the rat, cow and human pituitary was studied by a variety of techniques. Immunocytochemical detection showed a widespread expression of adrenomedullin peptide in the adenohypophysis and the neural lobe, with low expression in the intermediate pituitary. Proadrenomedullin N-20 terminal peptide (PAMP)-immunoreactivity was also present in the ant...

Journal: :Cancer research 2004
Alfredo Martínez Enrique Zudaire Sergio Portal-Núñez Liliana Guédez Steven K Libutti William G Stetler-Stevenson Frank Cuttitta

We have found through ex vivo and in vivo angiogenesis models that the adrenomedullin gene-related peptide, proadrenomedullin NH2-terminal 20 peptide (PAMP), exhibits a potent angiogenic potential at femtomolar concentrations, whereas classic angiogenic factors such as vascular endothelial growth factor and adrenomedullin mediate a comparable effect at nanomolar concentrations. We found that hu...

Journal: :journal of sciences islamic republic of iran 0

fabms analysis of t-lb peptide before and after one cycle of edman degradation indicated an unblocked n-terminal thr residue for this tryptic peptide. in contrast , our data showed a molecular protonated ion, mh + for t- la peptide at 655 mass units (mu) which is 42 mu higher than the mh ion of t- 1b peptide. in addition, t- la peptide was not amenable to one cycle of manual edman degradation. ...

FABMS analysis of T-lb peptide before and after one cycle of Edman degradation indicated an unblocked N-terminal Thr residue for this tryptic peptide. In contrast , our data showed a molecular protonated ion, MH + for T- la peptide at 655 mass units (mu) which is 42 mu higher than the MH ion of T- 1b peptide. In addition, T- la peptide was not amenable to one cycle of manual Edman degrada...

Journal: :The Journal of clinical investigation 1996
K Takano N Yamashita T Fujita

The effect of proadrenomedullin NH2-terminal 20 peptide (PAMP) on the voltage-gated Ca2+ channel current was investigated using the perforated whole-cell clamp technique on NGF-treated PC12 cells. PAMP inhibited the Ba2+ current through N-type Ca2+ channels in a concentration dependent manner. Injection of GDPbetaS into the cell abolished the inhibition while injection of GTPgammaS into the cel...

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