Background & Aims: Acute lymphoblastic leukemia (ALL) is the most common malignancies in the world. Despite advances in treatment of patients with ALL, a subset of patients will have recurrent disease or refractory to chemotherapy and hematopoietic stem cell transplant. Consequently, assessment of the effectiveness of natural compounds with high efficacy and minimal side effects is warranted. I...

Morrison, D. A. (Harvard College, Cambridge, Mass.). Prodigiosin synthesis in mutants of Serratia marcescens. J. Bacteriol. 91:1509-1604. 1966.-Exchange of biosynthetic intermediates through the culture medium was used to characterize several hundred new color mutants of Serratia marcescens. The general scheme of prodigiosin synthesis as a bifurcated pathway, in which monopyrrole and bipyrrole ...

Sir: Prodigiosin or prodigiosin-like antibiotic pigments are tripyrrole compounds synthesized by Serratia marcescens, Vibrio psychroerythrus, Pseudomonas magnesorubra and Alteromonas rubra as well as several genera of actinomycetes.1.2) Although the structures of several of the pigments are known, the site of localization and biosynthesis is less than clear.3,4) Studies of inhibition of prodigi...

An infection of the human oral cavity that is primarily fungal called Candida-associated denture stomatitis. Erythema palate and alveolar ridges are symptoms stomatitis, which a persistent inflammatory condition mucosa supporting dentures. So red pigment made by Serratia marcescens designated as prodigiosin was purified silica gel column chromatography with yield 3.7 g/l after being extracted a...

Vibrio is a genus of gram-negative, rod-shaped, motile bacteria commonly found in saltwater. One species particular, gazogenes PB1, sourced from an estuarine environment, known to produce the secondary metabolite, prodigiosin. This high-value compound has potential uses as antibiotic, fungicide, and anti-cancer agent. To further explore its metabolic genetic features for biotechnological purpos...

Prodigiosin is a red pigment produced by Serratia marcescens. Prodigiosin is regarded as a promising drug owing to its reported characteristics of possessing anti-microbial, anti-cancer, and immunosuppressive activity. A factorial design was applied to generate a set of 32 experimental combinations to study the optimal conditions for pigment production using crude glycerol obtained from local b...

different concentrations of gramicidin A. O 10 /Mg/ml, A 5 ^g/ml, å¡ 20 ^g/ml, ® 40 ^g/ml, ffl 40 ^g of gramicidin A/ml with only L-proline, A 40 fig of gramicidin A/ml alone and v is 40 jug of gramicidin A/ml and 300 fig of polymyxin B/ml without L-proline. Prodigiosin is a secondary metabolite produced by some strains of Serratia marcescens and other taxonomically unrelated bacteria. Some aut...