BACKGROUND Drug repurposing is a group of development strategies employed in order to overcome some of the hurdles innate to drug research and development. Drug repurposing includes drug repositioning, reformulation and combination. OBJECTIVE This study aimed to identify the determinants of successful market access outcome for drug repurposing in the United States of America (USA) and in Euro...

This study examined and compared the effects of consciousness-raisingwritten corrective feedback in 2 newly-developed levels in terms of marked thirdperson -s acquisition. Nine elementary level intact classes, including 191 malelanguage learners within the age range of 11-14 at Iran Language Institute, weretaken as the participants. Relying on the participants’ placement test results,previous t...

We introduce a reformulation technique that converts many-set feasibility problem into an equivalent two-set problem. This involves reformulating the original by replacing pair of its constraint sets with their intersection, before applying Pierra’s classical product space reformulation. The step combining two reduces dimension spaces. refer to this as reduction and use it obtain constraint-red...

In this paper, we consider a recently introduced cybersecurity investment supply chain game theory model consisting of retailers and consumers at demand markets with the retailers being faced with nonlinear budget constraints on their cybersecurity investments. We construct a novel reformulation of the derived variational inequality formulation of the governing Nash equilibrium conditions. The ...

A Standard Quadratic Optimization Problem (StQP) consists of maximizing a (possibly indefinite) quadratic form over the standard simplex. Likewise, in a multi-StQP we have to maximize a (possibly indefinite) quadratic form over the cartesian product of several standard simplices (of possibly different dimensions). Two converging monotone interior point methods are established. Further, we prove...

While some studies have investigated query reformulation in traditional online systems, there has been little understanding of how users reformulate their queries multiple times within search sessions on the Web. This paper reports on patterns and sequences of query reformulation based on query logs from a Web search engine. The data set contained only search sessions in which multiple query mo...