− Manassantin B, a dilignan isolated from Saururus chinensis, significantly inhibited proliferation in HSC-T6 cells in concentrationand time-dependent manners. In addition, treatment of HSC-T6 cells with manassantin B changed cell morphology from flattened myofibroblastic membranous morphology, representing activation state, to slender shape, representing quiescent state. Furthermore, manassant...

(Figure 1A,B). These results illustrate that DCC distribution is dynamically specified by developmental changes in gene expression. The aspect of transcriptional activity recognized by the DCC is unknown. Possibilities include chromatin features (e.g., nucleosome-free regions or variants and modifications of histones), or the transcription machinery itself. One suspect is histone H3 K4 methylat...

Dunn, G. (19746) Phytochemistry 13,1341-1346 Dunn, G., Hardie, D. G. & Manners, D. J. (1973) Biochem. J. 133,413-416 Gordon, R. W. (1974) Ph.D. Thesis, Heriot-Watt University Hardie, D. G. (1974) Ph.D. Thesis, Heriot-Watt University Hardie, D. G. & Manners, D. J. (1974) Carbohyd. Res. 36,207-210 Lee, E. Y. C. & Whelan, W. J. (1971) Enzymes5,192-234 Lee, E. Y. C., Marshall, J. J. & Whelan, W. J....

Some preliminary investigations of within-speaker variations due to voluntary and induced speaking manners have been performed. The ultimate aim of the investigations was to suggest methods to take care of within-speaker variations in automatic speaker verification. Special software was developed to systematically elicit different types of voluntary and involuntary speech variations that might ...