Abstract Background To compare the safety, efficacy, and tolerability of subcutaneous vaginal progesterone suppository for luteal phase support (LPS) in assisted reproduction technology (ART) cycles patients referred to Royan Institute. Methods This randomized clinical trial was conducted from August 2016 March 2018. The infertile undergoing vitro fertilization (IVF) and/or intracytoplasmic spe...

Astragalus polysaccharide (APS) (used for intestinal protection) was added to formulate the Tongshu suppository to improve the pharmacokinetics of Aceclofenac, which were assessed in New Zealand rabbits using an orthogonal experimental design. The single-agent Aceclofenac was taken as the control formulation. The concentration-time and drug release curves were drawn, and T max (min), C max (μg·...

Drug administration via mucosal membranes, including the vaginal, has the advantage of by passing the hepatogastrointestinal first pass metabolism associated with oral administration. Metronidazole suppositories were prepared using different suppository bases viz., water soluble bases ( PEGs and gelatin ) emulsion and fatty bases. The physicochemical properties of most of the prepared MTZ suppo...

Postoperative analgesia is one of the important objectives in women undergone Caesarean surgery. We, therefore, we dealt with the comparison of the analgesic effect between Acetaminophen and Indomethacin in post-Caesarean analgesia. This random clinical trial was performed on 200 women who had undergone Caesarean delivery in Shahrood’s hospitals in 2013 and were randomly placed in 4 groups of 5...

cancer pain. The oral route is the first choice in administering medication to relieve it, but clinical experience has shown that alternative routes of administration should be employed for patients suffering from nausea and vomiting. Furthermore, as morphine is subjected to the extensive first-pass metabolism after oral administration, the rectal administration of morphine, which can partially...