B7-DC is a recently discovered member of the B7 family that binds to PD-1 and is selectively expressed by dendritic cells (DCs). It has been shown to either costimulate or inhibit T cell responses. To assess the role of B7-DC in DC-T cell interactions, DCs from B7-DC knockout (KO) mice were generated and compared with DCs from wild-type (WT) and B7-1/B7-2 double KO mice. B7-1/B7-2-deficient DCs...

Endometrial cancer (EC) is the most frequent gynecological malignancy and a major cause of morbidity and mortality for women worldwide. Programmed cell death protein 1 (PD-1) and its ligands programmed death ligand 1 (PD-L1) and programmed death ligand 2 (PD-L2) have been well studied in lung cancer, melanoma and renal-cell cancer. However, few studies have been performed in EC. The purpose of ...

wheat is one of the most important crops in the world that is constantly faced with the different biotic and abiotic stresses. programmed cell death is one of the methods for coping with different stress which is stimulated by several factors. because salicylic acid is involved in resistance to various stresses, to explore the effects of salicylic acid on programmed cell death, the effects of s...

Although immune checkpoint inhibitors (ICIs) have provided a welcome paradigm shift in treating NSCLC with remarkable survival benefits some patients, their success has been tempered by low response rates and difficulty identifying accurate predictive biomarkers. Effective biomarkers to help identify responders, minimize unnecessary cost toxicity nonresponders, when use different combination tr...