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neuroinflammation is inflammation of the nervous tissue. it be initiated in response to infection, toxic metabolites, auto immunity, traumatic brain injury and variety of causes. exercise is a promising mechanism of prevention and treatment for disease characterized by neuroinflammation. the benefits of exercise and physical activity (pa) are well known and have effects on function of the centr...

background: probiotics are “live”, beneficial microbes that provide important health benefits in their hosts. there is significant interest in the modulation and regulation of the immune function by probiotics. objective: to investigate the immunomodulatory effects of a probiotic mixture, including lactobacillus and bifidobacterium species, by detecting serum cytokine and immunoglobulin levels....

background: a number of medicinal plants have been used to treat various immunological diseases. nitric oxide (no) has an important regulatory role in the various types of inflammatory processes. objective: to investigate the no modulatory activity of the extracts of several medicinal plants native to iran including dracocephalum kotschyi, linum persicum, dionysia termeana, salvia mirzayanii, f...

cancer immunotherapy (passive or active) involves treatments which promote the ability of the immune system to fight tumor cells. several types of immunotherapeutic agents, such as monoclonal antibodies, immune checkpoint inhibitors, non-specific immunomodulatory agents, and cancer vaccines are currently under intensive investigation in preclinical and clinical trials. cancer vaccines induce pe...

based on the evidence regarding the relationship between inflammatory processes and stress responses, the present study investigated the association between psychological stress and elevation of inflammatory mediators related to periodontal disease in adult patients.the study consisted of 50 patients including 25 patients with chronic periodontitis and 25 cases with aggressive periodontitis. tw...

introduction: knee osteoarthrosis is one of the most debilitating diseases. prolotherapy includes intraarticular injection of various drugs to decrease inflammation. injection of intradiscal o2-o3 has reduced pain and disability of patients with low back pain due to prolapsed lumbar disk. objective: to compare the effect of intraarticular injection of ozone and steroids in improvement of clinic...

background: the purpose of the present study was to compare the serum levels of il6 and ca125 in women with and without endometriosis. they were also compared in mild, moderate and severe cases. methods: in this case-control study, ca125 and il6 levels in 76 women with laparoscopic proven endometriosis were compared with 76 women without evidence of endometriosis. sensitivity, specificity, posi...

bacground: evidence from several lines of investigations suggests that toll-like receptor 4 (tlr4) is involved in atherosclerosis as a bridge between innate and acquired immunity. percutaneous coronary intervention (pci) can trigger inflammation through activation of human tlr4 (htlr4) on monocytes. hydrocortisone as an anti-inflammatory and immuno-suppressant agent has multiple mechanisms of a...