A case of histiocytic sarcoma developed primarily in the epididymis of B6C3F1 mouse at 109 weeks old was reported. Metastases were observed in the liver and adipose tissue of the abdominal cavity. Tumor cells showed atypism, pleomorphism and active erythrophagocytosis. Touton type giant cells, which were PAS positive after diastase digestion, were seen in the tumor. Electronmicroscopically, the...

Langerhans’ cell histiocytosis (LCH) is a proliferative histiocytic disorder of unknown origin. The lesions of LCH contain single or multifocal proliferation of histiocytes similar in phenotype to dendritic Langerhans’ cells (1). The disorder ranges in clinical severity from a solitary eosinophilic granuloma of bone to a generalised disease with multiple organ involvement. Primary involvement o...

Rosai-Dorfman disease (also known as sinus histiocytosis with massive lymphadenopathy) is a rare benign proliferative disorder of histiocytes that typically involves the lymph nodes and can also involve extranodal sites. Rosai-Dorfman disease confined to the breast is extremely rare, but important to recognize as it can mimic malignancy. We present the case of a 63-year-old woman who presented ...

Rosai-Dorfman disease (also known as sinus histiocytosis with massive lymphadenopathy) is a rare benign proliferative disorder of histiocytes that typically involves the lymph nodes and can also involve extranodal sites. Rosai-Dorfman disease confined to the breast is extremely rare, but important to recognize as it can mimic malignancy. We present the case of a 63-year-old woman who presented ...

INTRODUCTION Rosai-Dorfman disease (RDD) is a rare proliferative histiocytic disorder of unknown etiology. RDD typically presents with generalized lymphadenopathy and polymorphic histiocytic infiltration of the lymph node sinuses; however, occurrences of extranodal soft tissue RDD may rarely occur when masquerading as a soft tissue sarcoma. MATERIALS AND METHODS A comprehensive search of all ...

Cytophagic histiocytic panniculitis is a chronic histiocytic disease of the subcutaneous adipose tissue characterised by lobular panniculitis with histiocytes containing blood cell fragments. It is also associated with marked systemic features such as fever, pancytopenia, hepatosplenomegaly, liver abnormalities and coagulopathy. We report a case of cytophagic histiocytic panniculitis in a 74-ye...

Histiocytic sarcoma is a rare malignant neoplasm. It is well-known the association of Langerhans' cell histiocytosis with Hodgkin's disease but only few cases of histiocytic sarcoma associated with Hodgkin's disease was reported. We present the case of 20-years-old female patient with Hodgkin's disease with a sternal tumor mass which was diagnosed as histiocytic sarcoma. The diagnostic was esta...

Histiocytic sarcoma is a progressive and fatal malignant neoplasm that mainly occurs in middle- to old-aged dogs. This study describes clinicopathological, histological and immunohistochemical characteristics of intracranial histiocytic sarcomas in 23 dogs. Magnetic resonance imaging and/or computed tomography of the brains revealed that the tumors mainly located in the cerebrum, particularly t...

56 PRACTICAL DERMATOLOGY AUGUST 2014 R osai-Dorfman disease (RDD), or sinus histiocytosis with massive lymphadenopathy (SHML) is a benign lympho-histiocytic proliferative disorder initially described with bilateral painless lymphadenopathy (90 percent), fever, leukocytosis, elevated ESR, anemia, and polyclonal hypergammaglobulinemia (90 percent).1 RDD presents with cervical adenopathy most comm...