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Analyses of protein complexes are facilitated by methods that enable the generation of recombinant complexes via coexpression of their subunits from multigene DNA constructs. However, low experimental throughput limits the generation of such constructs in parallel. Here we describe a method that allows up to 25 cDNAs to be assembled into a single baculoviral expression vector in only two steps....
Genomic alterations lead to cancer complexity and form a major hurdle for comprehensive understanding of the molecular mechanisms underlying oncogenesis. In this review, we describe recent advances in studying cancer-associated genes from a systems biology point of view. The integration of known cancer genes onto protein and signaling networks reveals the characteristics of cancer genes within ...
background since 1986, the world health organization (who) has been motivating health sectors to promote clinical and curative services (who, 1986). some emergency departments (eds) have partially achieved this through providing patient health information, screening and early intervention programs, injury prevention, and asthma education. a significant organizational shift is required for eds t...
Mitotic exit in budding yeast is regulated by the proteins Cdc14, APC/C(Cdh1), and Plk1. In this issue, Bassermann and colleagues (2008) show that this network of proteins has been rewired in human cells to control the cell cycle in response to DNA damage.
PIK3R1 (encoding the p85α subunit of phosphatidylinositol 3-kinase) is the 11th most frequently mutated gene across tumors. We recently reported neomorphic p85α mutants that induce signaling cascades not predicted by the canonical functions of p85α, suggesting the need to functionally annotate specific mutations in cancer genes for effective genome-informed personalized therapy.
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