نتایج جستجو برای: prop1 gene
تعداد نتایج: 1141423 فیلتر نتایج به سال:
BACKGROUND/AIMS Central hypothyroidism (CH) in children is rare and may be due to a variety of genetic defects. Most of these defects, but not all, are associated with additional pituitary hormone deficits. In a young child presenting with CH, it is important to determine whether additional pituitary hormone deficiencies are present, but this may be difficult to establish clinically. METHODS ...
In laboratory mice, suppression of growth hormone (GH) signaling by spontaneous mutations or targeted disruption of GHor IGF1-related genes can lead to an impressive increase of longevity. Hypopituitary Ames dwarf (Prop1) and GH receptor knockout (GHRKO) mice live 35-70% longer than their normal littermates. Many phenotypic characteristics of these longlived mutants resemble findings in genetic...
We study the problem of fairly allocating indivisible goods and focus on classic fairness notion proportionality. The indivisibility is long known to pose highly non-trivial obstacles achieving fairness, a very vibrant line research has aimed circumvent them using appropriate notions approximate fairness. Recent work established that even versions proportionality (PROPx) may be impossible achie...
We reported recently that a pituitary-specific transcription factor PROP1 is present in SOX2-positive cells and disappears at the early stage of the transition from progenitor cell to committed cell during the embryonic development of the rat pituitary. In the present study, we examined the localisation and identification of SOX2-positive and PROP1/SOX2-positive cells in the neonatal and postna...
UNLABELLED Studies have demonstrated that flavonoid compounds of green propolis have antitumoral activity. STUDY DESIGN Experimental study. AIMS To evaluate the effect of a hydroalcoholic extract of green propolis (EPV) on chemically induced epithelial dysplasias in rat tongues. METHODS AND MATERIALS DMBA was brushed on the lingual dorsum of rats 3x/week on alternate days--100 (PROP1), 20...
OBJECTIVE Combined pituitary hormonal deficiency (CPHD) can result from mutations within genes that encode transcription factors. This study evaluated the frequency of mutations in these genes in a cohort of 144 unrelated Italian patients with CPHD and estimated the overall prevalence of mutations across different populations using a systematic literature review. MATERIAL AND METHODS A multic...
Auxological and endocrine phenotype in a population-based cohort of patients with PROP1 gene defects
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