several studies have shown that decidual tissue produces soluble factors which can mediate a variety of immunosuppressive activities. in order to assess whether prostaglandin e2 (pge2) was present in supernatants produced by explant culture of 10 human specimens of first trimester decidua. the effect of the supernatants from the two different series (with and without indomethacin treatment) of ...

the aqueous and ethanolic extracts of pedalium murex (pedaliaceae) was investigated for antipyretic activity in rats using brewer’s yeast-induced pyrexia models. brewer’s yeast (15%) was used to induce pyrexia in rats. both the extract (200 and 400 mg/kg body weight p.o produced a significant (p

It is suggested that COVID-19 (coronavirus) and other enveloped viruses can be inactivated by bioactive lipids. Bioactive lipids (BALs) AA, gamma-linolenic acid (GLA), dihomo-GLA (DGLA), eicosapentaenoic (EPA), docosahexaenoic (DHA) are precursors to anti-inflammatory metabolites prostaglandin E1, lipoxin A4, resolvins, protectins maresins enhance phagocytosis of macrophages leukocytes clear de...

Signal transducer and activator of transcription 3 (STAT3) has been considered as a potential target for development anticancer therapeutics. Here, we report novel mechanism by which the cyclopentenone prostaglandin, 15-deoxy-?12,14-prostaglandin J2 (15d-PGJ2) functions an allosteric inhibitor STAT3. 15d-PGJ2 inhibits phosphorylation, dimerization, nuclear translocation, transcriptional activit...

This study was designed to examine whether prostaglandin E2 can directly affect sodium transport across isolated perfused rabbit renal collecting tubules. Changes in transepithelial potential and isotopic sodium fluxes in response to peritubular prostaglandin E2 were measured. In addition, changes in transepithelial potential of the outer medullary collecting tubule in response to prostaglandin...

The highly purified prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes had two still unresolved enzyme activities; the oxygenative cyclization of 8,11,14-eicosatrienoic acid to produce prostaglandin G1 and the conversion of the 15-hydro-peroxide of prostaglandin G1 to a 15-hydroxyl group, producing prostaglandin H1. The latter enzymatic reaction required heme and was s...

We have investigated prostaglandin biosynthesis by human renal medullary and cortical microsomes with arachidonic acid as substrate. Prostaglandins were measured by two independent methods, namely radiometric thin layer chromatography and radioimmunoassay. The relative abundance of various prostaglandins synthesized by microsomes was similar in cortex and medulla. In the absence of added cofact...

Prostaglandin E2 plays a role in an array of pathophysiological responses, including inflammation, carcinogenesis and so on. Prostaglandin E2 is synthesized from arachidonic acid by the enzymes cyclooxygenase and prostaglandin E synthase. In some pathological conditions, the isozymes cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are transiently induced, leading to prostaglandin E2 ...

Endogenous uterine prostaglandin levels were monitored in the cycling rat and prostaglandins of the F-type were found to rise at proestrus when estrogen levels have been shown to be maximal. Evidence that this is an estrogen-induced event is furnished by the finding that estradiol-17beta caused a similar rise in prostaglandin F levels in uteri of ovariectomized rats, an action blocked by coadmi...

Angiotensin II stimulates prostaglandin release in blood vessels via activation of angiotensin receptors present in endothelium, vascular smooth muscle cells, or both. We evaluated the response of angiotensin II, angiotensin I, and [des-Phe8] angiotensin II [angiotensin-(1-7)] on prostaglandin release in porcine aortic endothelial cells. Incubation of cell monolayers with angiotensin I and angi...