Androgen-dependent normal prostatic glandular cells and androgen-dependent prostatic cancer cells can be induced to undergo cell death after androgen ablation. This death does not require the cells to proliferate and occurs as an energy-dependent process collectively referred to as "programmed cell death" in which the cells actively commit "suicide." Associated with this programmed cell death p...

OBJECTIVE We assessed the incidence of high-grade prostatic intraepithelial neoplasia (HGPIN) in prostates removed for bladder cancer, and evaluated its correlation with preoperative serum prostate specific antigen (PSA). MATERIALS AND METHODS We reviewed the histology of the prostate from men who underwent cystoprostatectomy for bladder cancer without known prostate pathology prior to surger...

The importance of polyamines in prostatic growth and differentiation has prompted studies to evaluate the clinical relevance of the ornithine decarboxylase/polyamine system in prostatic cancer. These studies show that differences in biological behaviour of prostatic (cancer) cells are associated with changes in polyamine levels and/or the activity of their metabolic enzymes. Faulty antizyme reg...

we report a case of prostatic adenocarcinoma, initially presenting with generalized lymphadenopathy, and mimicking lymphoma on flurodeoxyglucose positron emission tomography/computed tomography (fdg pet/ct). our case suggests that in elderly men presenting with generalized lymphadenopathy, the diagnosis of metastatic prostatic carcinoma should not be overlooked even in the absence of typical ur...

BACKGROUND Susceptibility weighted imaging (SWI) is a new MRI technique which has been proved very useful in the diagnosis of brain diseases, but few study was performed on its value in prostatic diseases. The aim of the present study was to investigate the value of SWI in distinguishing prostate cancer from benign prostatic hyperplasia and detecting prostatic calcification. METHODOLOGY/PRINC...

The daily percentage of cells proliferating and dying were determined for normal, premalignant, and cancerous prostatic cells within the prostate as well as for prostatic cancer cells in lymph node, soft tissue, and bone metastases from untreated and hormonally failing patients. These data demonstrate that normal prostatic glandular cells have an extremely low but balanced rate of cell prolifer...

Anacardic acid, which is commonly seen in plants of Anacardiaceae, is an important composition of cashew, ginkgo leaf and fruit, and it has been suggested in previous research to show antitumor activity. The main aim of the present study was to evaluate the anticancer effects of anacardic acid on cell apoptosis of prostatic cancer and molecular mechanisms of this phenomenon. In this study we fo...

conclusions regular resistance training and prostatic massage can improve proinflammatory markers and psa levels in men with pc. results in the resistance training group, il-10 levels significantly increased after four (p = 0.055) and eight weeks (p = 0.000). four and eight weeks of resistance training showed a significant reduction in psa, crp, il-6, and tnf-α levels (p < 0.05). patients of ma...

Benign prostatic hyperplasia refers to an anatomic diagnosis, yet in practice it is typically diagnosed clinically on the basis of lower urinary tract symptoms and prostatic enlargement detected on manual rectal examination or transrectal ultrasonography (1). Over the past decade, since benign prostatic hyperplasia (2) and prostate cancer (3) were reviewed in this Journal, there has been a prol...

In the United States, 1987 estimates of cancer incidence by site indicate that prostatic is equal to lung as first in adult males. Over 90,000 new cases are diagnosed and between 25-30,000 patients die this disease each year. While early a surgically curable disease, majority present with widely metastatic cancer, where main objective treatment palliation.