objective(s): despite treatment with antibiotics and vaccination with bcg, tuberculosis (tb) is still considered as one of the most important public health problems in the world. therefore, designing and producing a more effective vaccine against tb seems urgently. in this study, immunogenicity of a fusion protein which consisting or comprising cfp-10 from mycobacterium tuberculosis and the fc-...

conclusions it is important to consider tb meningitis in newborns with perinatal ivh and concomitant hydrocephalus particularly when the mother has a history of tb prior to or during pregnancy. introduction congenital tuberculosis is an infrequently encountered condition and only 300 cases were reported in the literature till 1989. there are no specific signs and symptoms pathognomonic for cong...

Tuberculosis (TB) serological testing with antigen complexes, although very sensitive, is not always as specific due to reactive serum antibodies in patients with inactive TB or nontuberculous infections. Since the use of recombinant M. tuberculosis proteins may enhance specificity, this study was designed to evaluate a novel 34 kDa tuberculosis complex-specific protein as a component of an ant...

An evaluation of the humoral response based on secretory immunoglobulin A levels in the saliva of pulmonary tuberculosis (TB) acid-fast bacillus-positive (TB-AFB+) patients against a recombinant 38 kDa antigen (Ag38-rec) is reported. A total of 60 saliva samples consist of 30 TB-AFB+ patients and 30 healthy controls were tested against 500 ng of semi-purified antigen using the dot blot method. ...

The DNA/RNA-binding protein, Translin/Testis Brain RNA-binding protein (Translin/TB-RBP), contains a putative GTP binding site in its C-terminus which is highly conserved. To determine if guanine nucleotide binding to this site functionally alters nucleic acid binding, electrophoretic mobility shift assays were performed with RNA and DNA binding probes. GTP, but not GDP, reduces RNA binding by ...

What methods would you choose apart from purified protein derivative (PPD) skin test and culture for acid-fasting bacilli (AFB) to make a clinical diagnosis of pulmonary tuberculosis (TB) in an aged patient with possible TB? These are two cases TB, that occurred persistent low-grade fever, fatigue anorexia due mild toxemia tuberculosis. A final was established on the basis toxemia(low-grade fev...

Introduction. The development of effective test systems for tuberculosis (TB) diagnosis and the study factors influencing their sensitivity specificity constitute urgent tasks given unstable epidemiological situation with TB in Ukraine world. aimed to determine clinical laboratory features pulmonary that may affect IgG antibody detection human serum by immuno-enzyme system “IB-Chem Anti-Mycobac...

Toddlers in South Kalimantan who experience nutritional problems on indicators of Weight/Height, namely underweight category, at a prevalence 5.5% above national figure 3.9%. Data from Guntung Payung Health Center showed there 38% under-fives with status and 9% very thin status. One preventive measures for undernourished toddlers is provision supplementary food containing high protein. Research...

multidrug-resistant (mdr) and extensively drug-resistant (xdr) tuberculosis (tb) are increasing globally. treatment options for these patients are very limited. although treatment of these patients with standardized regimen is associated with high mortality and morbidity, rational usage of new drugs might be promising. in this study we will review epidemiology of xdr-tb and tdr-tb in iran and t...

BACKGROUND The diagnosis of smear-negative pulmonary tuberculosis (TB) is problematic. There are limited data on the profile of alveolar TB antigen-specific T cells, and their utility for the rapid immunodiagnosis of pulmonary TB is unclear. METHODS Antigen-specific interferon gamma (IFNgamma) responses to the RD-1 antigens ESAT-6 and CFP-10 (T-SPOT.TB and QuantiFERON-TB-Gold-In-Tube), hepari...