OBJECTIVE To evaluate the diagnostic value of prostate-specific antigen density (PSAD) and the appropriate cutoff for the detection of prostate cancer. MATERIAL AND METHOD Between January 2008 and March 2011, 292 men with PSA levels between 4 and 10 ng/mL underwent transrectal ultrasonography (TRUS) with prostate biopsy. The diagnostic value of PSA levels and PSAD were compared using receiver...

P antigen (PSA) is a serine protease produced by the prostate gland at very high concentrations. PSA is secreted into the seminal plasma in high concentrations (0.5 to 5 g/L), where it plays a role in semen liquefaction. The retrograde release of PSA into the bloodstream is a rare event in young, healthy men. It occurs with a frequency of less than one PSA molecule per million secreted PSA mole...

OBJECTIVE The aim of this study was to determine the incidence of asymptomatic, histologically proven prostatitis in men with symptoms of benign prostate hyperplasia and to observe the correlation between asymptomatic prostatitis and prostate specific antigen (PSA) density. INTRODUCTION The incidence of type IV prostatitis is unknown. There is a tendency to correlate the presence of inflammat...

OBJECTIVE Compare the capacity of the PSA density (PSAD), Free PSA percentage (%FPSA) and PSA transition zone density (PSATZ) in improving the sensitivity and specificity of the PSA to detect prostate cancer (PCa) in men with a PSA between 4 and 10 ng/mL. MATERIALS AND METHODS One hundred and forty five men with PSA between 4 and 10 ng/mL were prospectively studied. Blood collection for the t...

The purpose of this study was to investigate the Prostate-Health-Index (PHI) for pathological outcome prediction following radical prostatectomy and also for biochemical recurrence prediction in comparison to established parameters such as Gleason-score, pathological tumor stage, resection status (R0/1) and prostate-specific antigen (PSA). Out of a cohort of 460 cases with preoperative PHI-meas...