Although pseudomembranous colitis is relatively common following antibiotic exposure, there have been few reported cases of pseudomembrane formation involving the small intestine. Herein we report a case of pseudomembranous enteritis of the small and large intestine that occurred after antibiotic exposure. The etiologic organism appears to be Clostridium difficile, as evidenced by the character...

Pseudomembranous colitis (PMC) is an inflammatory disorder usually limited to the large intestine and is the consequence of antibiotic associated Clostridium difficile overgrowth with production of its toxin. It has a characteristic gross and microscopic appearance. PMC-like changes, usually associated with peri-operative hypotension and with more extensive gastrointestinal tract involvement, h...

Vancomycin and cholestyramine have been utilized both alone and in combination for the treatment of antibiotic-associated pseudomembranous colitis. Previous work for the treatment of antibiotic-associated pseudomembranous colitis. Previous work has demonstrated significant binding of vancomycin by the anion-exchange resin. The antibacterial activity of vancomycin was markedly reduced when the s...

Goldstein HH. Allergy and diabetes. In: Joslin's diabetes mellitus. 11th edn. Philadelphia: Lea and Febiger, 1971. 2 Leslie D. Generalised allergic reaction to monocomponent insulin. Br MedJ 1977;ii :736-7. 3 Sewell H, Smith DI, Willox A, Barnes CA, Matthews JB. Demonstration of islet cell antibodies. Lancet 1980;i :102-3. 4 Davidson JA, Galloway JA, Peterson BH, et al. The use of purified insu...

Fulminant colitis can be a sequelae of a number of conditions like Salmonellae, Shigella, E. Coli, Yersinia and other bacterial infections. Antibiotic associated pseudomembranous colitis is caused by clostridiuin difficle and can range from mild diarrhoea to fulminant colitis. Furthermore, chronic conditions like ulcerative colitis and Crohn’s disease can cause acute symptoms. Non-specific coli...

Hospitalized patients receiving β lactam antibiotics develop diarrhea and higher rates reported in those receiving clindamycin. Clostridiumdifficile is recognized as a cause of antibiotic associated diarrhea, colitis and pseudomembranous colitis. Contributory factors include: advance age, severity of underlying illness.C.difficile has the ability to temporarily colonize newborn humans and calve...

Background. Diagnosis and management of Clostridium difficile infection (CDI) rely upon clinical assessments and diagnostic studies. Among diagnostic tests, lower gastrointestinal (GI) endoscopy in the setting of CDI remains controversial. Objective. To describe the role of lower endoscopy in CDI management. Methods. Retrospective study of lower endoscopies in CDI at four metropolitan hospitals...