Twelve patients with personality disorders or chronic schizophrenia in whom aggressive-destructive behaviour was a prominent feature were treated by bilateral stereotaxic electrocoagulation of the amygdala. In two of the patients a cingulectomy and in five of the patients a frontal lobotomy had been performed several years previously without effect. In 11 of the patients the amygdalotomy result...

6.1.0 Introduction Olanzapine, chemically known as 2-Methyl-4-(4-methyl-1-piperazinyl)-10Hthieno [2, 3-b] [1, 5] benzodiazepine, is a potential antipsychotic agent used in chemotherapy. It has been approved by the food and drug administration (FDA) and it is one of the most commonly used atypical anti psychotics. It is used in the treatment of schizophrenia, acute mania in bipolar disorder, agi...

The patbogenesis of NMS is still debated though evidence in favour of central dopaminergic blockade is more convincing and against peripheral toxic effect on skeletal muscles. Very few cases have been reported from tropical and sub tropical countries. Seven cases of NMS admitted in the Department of Neuropsychiatry, Jinnah Fostgraduate Medical Centre, Karachi are being reported. All were acutel...

Identifying new indications for existing drugs (drug repositioning) is an efficient way of maximizing their potential. Adverse drug reaction (ADR) is one of the leading causes of death among hospitalized patients. As both new indications and ADRs are caused by unexpected chemical-protein interactions on off-targets, it is reasonable to predict these interactions by mining the chemical-protein i...

Behavioral and psychological symptoms of dementia (BPSD), i.e. verbal and physical aggression, agitation, psychotic symptoms (hallucinations and delusions), sleep disturbances, oppositional behavior, and wandering, are a common and potentially severe problem complicating dementia. Their prevalence is very high and it is estimated that up to 90% of patients with Alzheimer's disease (AD) may pres...

INTRODUCTION This study assesses the potential eligibility of patients admitted to a psychiatric hospitalisation unit to take part in the major clinical trials based on schizophrenia treatment in clinical practice (CATIE, CUtLASS and EUFEST). MATERIAL AND METHODS A retrospective evaluation by consulting the medical records of 241 subjects (59.8% males and 40.2% females, mean age 39.7±13.0 yea...

Studies of the circadian rhythm in plasma 11-O.H.C.S. levels showed that a subgroup of affective psychotics had higher plasma 11-OHCS values as compared with schizophrenic and other psychotic subgroups, and a somewhat less regular rhythm. One patient with depression who was studied over 48-hour periods showed a reduction in plasma 11-OHCS levels with clinical recovery. An accentuated fall and r...

Are islamic terrorists insane? International scholars generally concede that Al Qaeda members are not mentally ill. But, until now, there has not been a shared consensus and a strong argument that can prove it. This paper intends to throw light on the specific dehumanization of terrorists and to show that they are always responsible for their acts, unlike those who are affected by mental diseas...