نتایج جستجو برای: pteridine reductase 1
تعداد نتایج: 2784388 فیلتر نتایج به سال:
Genetic studies indicate that the enzyme pteridine reductase 1 (PTR1) is essential for the survival of the protozoan parasite Trypanosoma brucei. Herein, we describe the development and optimisation of a novel series of PTR1 inhibitors, based on benzo[d]imidazol-2-amine derivatives. Data are reported on 33 compounds. This series was initially discovered by a virtual screening campaign (J. Med. ...
Pteridine reductase-1 (PTR1) is a promising drug target for the treatment of trypanosomiasis. We investigated the potential of a previously identified class of thiadiazole inhibitors of Leishmania major PTR1 for activity against Trypanosoma brucei (Tb). We solved crystal structures of several TbPTR1-inhibitor complexes to guide the structure-based design of new thiadiazole derivatives. Subseque...
The Synthesis and Characterization of Ru(bpy)2(L-pteridine) and Ru(phen)2(L-pteridine) complexes Ruthenium (II) polypyridyl complexes are very important biochemical compounds because of their interactions with DNA. In this study, these complexes are analyzed to understand how their physical properties, chemical properties, and interactions with DNA are affected by structural differences of the ...
The study of antifolate-resistant mutants of the protozoan parasite Leishmania has provided useful information about genetic processes such as gene amplification and mutation and knowledge of the unique features of the pteridine metabolic pathway in this primitive eukaryote. The novel bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) is an essential enzyme, yet most DHFR-TS in...
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