نتایج جستجو برای: pttg1
تعداد نتایج: 301 فیلتر نتایج به سال:
Background: Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiovascular disease and the most common cause of sudden cardiac death in the young. Over 24 genes have been implicated in the pathogenesis of HCM. However, for about half of patients with HCM, the genotypic substrate remains elusive. A recent study showed that male TGF Inducible Early Gene-1 (TIEG1) knock-out (TIEG1) ...
Cross-resistance to molecules used in endocrine therapy is among the main challenges in the treatment of estrogen receptor-alpha (ERalpha) positive breast cancer. In this study, we used two different cell models of resistance to anti-estrogens: MVLN/CL6.7 cells and VP229/VP267 cells selected after exposure to tamoxifen respectively in vitro and in vivo to characterize a phenotype rarely observe...
The Distinction between malignant and benign pheochromocytoma has always been a diagnostic challenge over the last decades. To date, the only reliable criterion is metastasis. The aim of the present study was to investigate the possible expression of pituitary-tumor transforming gene (PTTG1) and retinoblastoma (Rb) in benign and malignant pheochromocytoma. Paraffin blocks of 44 and 11 patients ...
the distinction between malignant and benign pheochromocytoma has always been a diagnostic challenge over the last decades. to date, the only reliable criterion is metastasis. the aim of the present study was to investigate the possible expression of pituitary-tumor transforming gene (pttg1) and retinoblastoma (rb) in benign and malignant pheochromocytoma. paraffin blocks of 44 and 11 patients ...
Meningiomas are frequent central nervous system tumors. Although most meningiomas are benign (WHO grade I) and curable by surgery, WHO grade II and III tumors remain therapeutically challenging due to frequent recurrence. Interestingly, relapse also occurs in some WHO grade I meningiomas. Hence, we investigated the transcriptional features defining aggressive (recurrent, malignantly progressing...
Different mutations in the human Crumbs homolog-1 (CRB1) gene cause a variety of retinal dystrophies, such as Leber congenital amaurosis, early onset retinitis pigmentosa (e.g., RP12), RP with Coats-like exudative vasculopathy, and pigmented paravenous retinochoroidal atrophy. Loss of Crb1 leads to displaced photoreceptors and focal degeneration of all neural layers attributable to loss of adhe...
The aim of the present study was to identify potential therapeutic targets for lung cancer and explore underlying molecular mechanisms of its development and progression. The gene expression profile datasets no. GSE3268 and GSE19804, which included five and 60 pairs of tumor and normal lung tissue specimens, respectively, were downloaded from Gene Expression Omnibus. Differentially expressed ge...
Lung cancer is the leading cause of cancer deaths in both genders worldwide, with an incidence only second to prostate cancer in men and breast cancer in women. The lethality of the disease highlights the urgent need for innovative therapeutic options. Immunotherapy can afford efficient and specific targeting of tumor cells, improving efficacy and reducing the side effects of current therapies....
Abstract Background Pituitary tumor transforming genes (PTTG1, PTTG2, and PTTG3P) play key roles in the pathogenesis development of human cancers. The studies show that overexpression PTTG is associated with progression migration. However, function prognostic value kidney renal clear cell carcinoma rarely known by people. Methods expression family was analyzed ONCOMINE, Human Protein Atlas, GEP...
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