background and objectives: cancer is a public health problem all over the world. herbal medicines have a vital role in the prevention and treatment of cancer and large numbers of plants and their isolated constituents have shown potential anticancer activity. methods: twenty seven medicinal plants from southern iran provinces have been extracted with methanol and screened for their cytotoxic ac...

it has been reported that several members of convolvulaceae family such as convolvulus arvensis possess cytotoxic activity on some tumor cell lines. proteoglycan mixture, the water extract of c. arvensis with high molecular weight, has potent anti-angiogenesis and stimulating effects. in this study, arial parts of c. arvensis were collected and identified, and the cytotoxic effects of chlorofor...

PURPOSE The survival of retinal ganglion cells (RGCs) is a hallmark of many optic neurodegenerative diseases such as glaucoma. YC-1, a potential anticancer drug, is known to be able to decrease the stability and protein expression of hypoxia-inducible factor (HIF)-1α that is triggered by hypoxia and related to RGC survival. We hypothesized that YC-1 may alter RGC cell viability through the down...

background: although pentavalent antimony compounds are used as antileish-manial drugs but they are associated with limitations and several adverse complica-tions. therefore, always effort to find a new and effective treatment is desired. in this study, the effect of zno nanoparticles with mean particle size of 20 nanome-ters (nm) on leishmania major promastigotes and amastigotes was evaluated....

OBJECTIVE To explore the toxicological mechanism of hydroquinone in human bronchial epithelial cells and to investigate whether DNA polymerase beta is involved in protecting cells from damage caused by hydroquinone. METHODS DNA polymerase beta knock-down cell line was established via RNA interference as an experimental group. Normal human bronchial epithelial cells and cells transfected with ...

65 2.1 Material and Methods 66 2.1.1 Plasmid and cloning 66 2.1.2 Cell culture and transfection 66 2.1.3 Assessment of cell viability 67 2.1.4 Assessment of Neurite process length and branching point. 68 2.1.5 Ras Pull-Down Assay 68 2.1.6 Generation of Human LRRK2 Transgenic Flies. 69 2.1.7 Western Blot Analysis. 70 2.1.8 Immunoprecipitation. 71 2.1.9 Optical Neutralization Technique. 71 2.1.10...

Objective(s): To explore the correlation between expression patterns and functions of miR-383 and LDHA in hepatocellular cancer (HCC). Materials and Methods: We detected the expression of miR-383 and LDHA in 30 HCC tissues and their matched adjacent normal tissues using qRT-PCR. Then we performed MTT assay, foci formation assay, transwell migration assay, glucose uptake assay and lactate produc...

iran has 1260 km of coastline that borders the persian gulf and the oman sea in the northwest indian ocean. marine algae are one of the natural resources in the marine ecosystem which produce a wide range of new secondary metabolites with various biological activities that play an important role in the pharmaceutical care. in this study the cytotoxic activity of 28 marine algae of chabahar coas...