The diagnosis and management of three cases of pulmonary alveolar proteinosis are described. The electron microscopic appearances of lung biopsy material, lung washings, and sputum and the value of this method of sputum examination in extremely ill patients are demonstrated. The practical details of controlled volume bronchial lavage are described and the good clinical and physiological respons...

A 35 years old man presented with primary pulmonary alveolar proteinosis who was admitted to chest unit of ATH through casualty department. Before he came to our ward he was treated with different antibiotics including anti-tuberculosis drugs for a month at least. But his symptoms did not improve rather his dyspnoea got worse. He was misdiagnosed till histopathology revealed that he has pulmona...

Crazy paving pattern is a finding on computed tomography of the chest that is characterized by interlobular septal thickening and ground-glass opacities. Though classically associated with pulmonary alveolar proteinosis, the differential diagnosis for this pattern is broad, and initial workup includes bronchoscopy with bronchoalveolar lavage to evaluate for malignancy, diffuse alveolar hemorrha...

Pulmonary alveolar proteinosis is a rare but potentially treatable disease, characterized by impaired surfactant metabolism that leads to accumulation in the alveoli of proteinaceous material rich in surfactant protein and its component. Novel insights from an animal model aided the discovery of granulocyte macrophage colony stimulating factor (GM-CSF) antibodies as a pathogenetic mechanism in ...

BACKGROUND AND OBJECTIVES Pulmonary Alveolar Proteinosis (PAP) is a rare disorder first described in 1958. The Whole-Lung Lavage (WLL) proposed in the 1960s, remains the treatment of choice. Several techniques have been described to perform lung lavage in pediatric patients; however, all have limitation and risks. CASE REPORT Female patient, aged 6 years and 8 months, 25 kg, diagnosed with pu...

INTRODUCTION Pulmonary alveolar proteinosis is characterized by accumulation of surfactant and phospholipids in the pulmonary alveoli. Whole lung lavage is considered the first-line therapy, which requires special techniques. To the best of our knowledge, there have only been limited reports that have demonstrated the effectiveness of ambroxol on a mild case of pulmonary alveolar proteinosis. ...

I N a now classic article, Rosen and associates1 described an alveolar filling disease which they named pulmonary alveolar proteinosis. This disorder is of unknown origin and usually occurs as a primary process, although it may also be seen in association with hematologic neoplasms.2 In alveolar proteinosis the distal air spaces become filled with a lipoproteinaceous material that has chemical ...