this case report describes the treatment of two immature maxillary central incisors in a 7- year-old female patient. she suffered complicated crown fracture because of trauma, and the root formation was incomplete. white mineral trioxide aggregate (mta) was selected as the pulp-capping material after cervical pulpotomy to preserve the pulp tissue vitality and achieve maturogenesis. follow-up ev...

Endodontic treatment of immature necrotic teeth is a real challenge. Recently, a biologically based treatment strategy, referred to as regeneration, has been introduced. Tissue regeneration requires the presence of stems cells, a scaffold, and growth factors. Endodontic regeneration may improve the prognosis of immature necrotic teeth by re-establishing the functional pulpal tissue and further ...

dental pulp stem cells (dpscs) can be found within the cell rich zone of dental pulp. these stem cells, under specific stimuli, differentiate into many cell types which have wide therapeutic applications.   the dental stem cells are derived from both deciduous and permanent teeth. the viable dental stem cells are very simple to collect, without any mortality and morbidity. dental pulp stem cell...

INTRODUCTION The health of human teeth depends on the integrity of the hard tissue and the activity of the pulp and periodontal tissues, which are responsible for nutritional supply. Without the nourishing of the pulp tissue, the possibility of tooth fracture can increase. In immature permanent teeth, root development may be influenced as well. This study explored the potential of using autolog...

Avian feathers have robust growth and regeneration capability. To evaluate the contribution of signaling molecules and pathways in these processes, we profiled gene expression in the feather follicle using an absolute quantification approach. We identified hundreds of genes that mark specific components of the feather follicle: the dermal papillae (DP) which controls feather regeneration and ax...

stem cell-based therapy has great potential in treating health conditions including cardiovascular, autoimmune, type i diabetes, neurodegenerative and bone and cartilage diseases also in spinal cord injuries, malformations and cancer. in addition to their potential use to treat systemic diseases, stem cell-based therapy also provides a powerful tool to treat oral and dental diseases such as cra...

INTRODUCTION Migratory cells via blood circulation or cells adjacent to the root apex may potentially participate in dental pulp tissue regeneration or renewal. This study investigated whether systemically transplanted bone marrow cells can contribute to pulp regeneration in a chimeric mouse model. METHODS A chimeric mouse model was created through the injection of bone marrow cells from gree...

In organs, multiple functionally differentiated cells and stem are organized to express specific functions through a series of complex interactions. The Wnt signaling pathway is deeply involved in these processes throughout life. dependence on spatiotemporal specificity the changes vivo interactions caused by balance distribution ligands antagonists. Regeneration thought involve reconstitution ...

This review outlines the biological basis and clinical protocols currently used in regenerative endodontic procedures (REPs) and discuss future directions in pulp regeneration approaches. The treatment of immature teeth with REPs has been described as a 'paradigm shift' as there is the potential for further root maturation. Clinically, REPs involve disinfection of the root canal system without ...