The cardiovascular disease is one of most frequent cause deaths in modern society. The objective of this work is analyse the effect of dynamic vascular geometry (curvature, torsion, bifurcation) and pulsatile blood nature on secondary flow, wall shear stress and platelet deposition. The problem was examined as multi-scale physical phenomena using perturbation analysis and numerical modelling. T...

BACKGROUND It is a known fact that blood flow pattern and more specifically the pulsatile time variation of shear stress on the vascular wall play a key role in atherogenesis. The paper presents the conception, the building and the control of a new in vitro test bench that mimics the pulsatile flows behavior based on in vivo measurements. METHODS An in vitro cardiovascular simulator is alimen...

The theory of dynamic fluid motion involving the forces manifested by mass, acceleration, viscous friction and vessel wall tension have been considered and studied when arterial blood flow and pressure are pulsatile. These studies and considerations have resulted in the conclusion that arterial blood pressure is dependent upon all of these parameters and that the relationship of pressure and fl...

The heart’s natural provision of pulsatile blood flow has been regarded as an essential requirement for normal organ function, especially critical organs such as the kidney, liver, and brain. However, in this issue of Circulation, Russell and colleagues1 have demonstrated that this tenet of medicine is no longer accurate. Their study examined the long-term impact of nonpulsatile blood flow as p...

OBJECTIVE Various types of rotary blood pumps (axial flow, centrifugal) have been introduced into clinical use recently. These pumps have different pressure-flow characteristics, and some investigators have noted that a limited pump flow rate and less pulsatility are the problems with the axial flow devices. METHODS A new implantable centrifugal blood pump was developed that has an extremely ...

AIM Leg compression bandaging is the mainstay of venous ulcer treatment, yet little is known about the impact of therapeutic compression levels on arterial haemodynamics. In this study, the effect of foot-to-knee, four-layer compression bandaging on below-knee arterial pulsatile blood flow was assessed by nuclear magnetic resonance flowmetry. METHODS In 14 healthy supine subjects, bilateral p...

The purpose of this paper is to present a numerical simulation system for blood flow in the carotid artery bifurcation and its validation using experimental data collected in clinical practice. Blood flow is described by the incompressible Navier-Stokes equations and the simulation is carried out under pulsatile conditions using inlet velocities given by a flow wave form obtained by ultrasound ...