Hippocampal synaptic inhibition is mediated by distinct groups of inhibitory cells. Some contact pyramidal cells perisomatically, while others terminate exclusively on their dendrites. We examined perisomatic and dendritic inhibition by recording from CA3 inhibitory and pyramidal cells and injecting biocytin to visualize both cells in light and electron microscopy. Single perisomatic inhibitory...

Both circuit and single-cell properties contribute to network rhythms. In vitro, pyramidal cells exhibit theta-band membrane potential (subthreshold) resonance, but whether and how subthreshold resonance translates into spiking resonance in freely behaving animals is unknown. Here, we used optogenetic activation to trigger spiking in pyramidal cells or parvalbumin immunoreactive interneurons (P...

Animal studies have shown that prenatal stress is able to induce long-lasting neurobiological and behavioral alterations in adult offspring. In spite of the facts that hippocampus is sensitive to early developmental influences and its known functional importance in learning and memory, few data are available on the effect of prenatal stress on the structure of hippocampus. Therefore, this study...

The cortical circuit includes networks of highly interconnected pyramidal neurons. Here, we investigated whether pyramidal cells form subnetworks depending on pyramidal subtypes. We classified layer V (L5) pyramidal cells in rat frontal cortex into three physiological subtypes based on the presence (SA-d type) or absence (SA type) of an initial burst in neurons displaying slowly adapting spike ...

Simultaneous intracellular recordings were obtained from stratum lacunosum-moleculare (L-M) interneurons and CA1 cells, and their local circuit synaptic interactions were examined. Synaptic interactions with pyramidal cells were evaluated in both intrasomatic and intradendritic pyramidal cell recordings. Stimulation of L-M interneurons evoked small-amplitude IPSPs in 21% of intrasomatic (9/42 c...

The neocortical circuit is composed of excitatory principal neurons and inhibitory interneurons. Recent advances have established that multiple subnetworks of synaptically coupled excitatory neurons provide distinct pathways for information flow through the cortical circuit. Here we have investigated how inhibitory interneurons are incorporated into these excitatory subnetworks in the rat front...

background & aim: in traditional medicine, boswellia species gum resin known as frankincense or olibanum, has been administrated in elderly for enhancement of memory and also in pregnant women to increase memory and intelligence of progeny. however, it has been rarely scientifically documented so far. we have previously reported that maternal administration of frankincense during lactation ...

The interplay between principal cells and interneurons plays an important role in timing the activity of individual cells. We investigated the influence of single hippocampal CA1 pyramidal cells on putative interneurons. The activity of CA1 pyramidal cells was controlled intracellularly by current injection, and the activity of neighboring interneurons was recorded extracellularly in the uretha...

Dual whole-cell recordings were made in layer 2/3 of the rat neocortex in synaptically connected pyramidal cells and fast-spiking non-accommodating (FSN) interneurons. In 75% of cell pairs (n = 80), the cells formed reciprocal synaptic connections. Trains of backpropagating action potentials in pyramidal cells induced Ca2+ transients in dendrites followed by inhibition of unitary IPSPs. IPSP de...