This work deals with limit cycles of real planar analytic vector fields. It is well known that given any limit cycle Γ of an analytic vector field it always exists a real analytic function f0(x, y), defined in a neighbourhood of Γ, and such that Γ is contained in its zero level set. In this work we introduce the notion of f0(x, y) being an m-solution, which is a merely analytic concept. Our mai...

background and objectives:drimia maritima (l.) stearn also known as squill is a medicinally important plant that has been used for various ailments such as dropsy, respiratory disorders, jaundice and epilepsy from ancient times. proscillaridin a is identified as one of the most effective compounds in the plant with remarkable pharmacological features including efficacy against congestive heart ...

A simple, specific and accurate reverse phase high performance liquid chromatographic method was developed for the determination of cyclosporine in capsule dosage form. XTerra C18 column was used as stationary phase with mobile phase acetonitrile in combination with 0.1% trifluoro acetic acid buffer and pH is adjusted to 1.4. Method was developed in an isocratic run of 20% trifluoro acetic acid...

A simple, specific, accurate, and precise reverse phase liquid chromatographic method was developed and validated for the estimation of risperidone in tablet dosage forms. A Phenomenex Gemini C-18, 5 mum column having 250x4.6 mm i.d. in isocratic mode, with mobile phase containing methanol: acetonitrile: 50 mM potassium dihydrogen orthophosphate (80:10:10 v/v) was used. The flow rate was 1.3 ml...

AIM To investigate and compare the analytical and clinical performance of TianLong automatic hypersensitive hepatitis B virus (HBV) DNA quantification system and Roche CAP/CTM system. METHODS Two hundred blood samples for HBV DNA testing, HBV-DNA negative samples and high-titer HBV-DNA mixture samples were collected and prepared. National standard materials for serum HBV and a worldwide HBV D...

Pregabalin is an antiepileptic and analgesic drug, commercialized under the name of Lyrica, and generally used to treat neuropathic pain. The determination of pregabalin was performed by using spiked hair samples extracted in methanol and analyzed by ultra-high-performance liquid chromatography coupled with tandem mass spectrometry. The validation of a quantification method of pregabalin in hai...

A 61-year-old man presented with an increased anion-gap metabolic acidosis, an increased serum osmolal gap, and a negative result in an alcohol screen. Gas chromatography revealed an increased ethylene glycol (EG) concentration (22 mg/dL) and a propylene glycol (PG) result that was below the lower limit of quantification ( 5 mg/dL) (Fig. 1A). The patient was treated with hemodialysis, followed ...

Results At incision performed 158 ± 112 min after administration, cefpirome concentrations in abscess ranged from below the limit of quantification to 47 mg/L (8.4 ± 14.1 mg/L), and moxifloxacin concentrations ranged from below the limit of quantification to 9.2 mg/L (1.9 ± 3.4 mg/L). Relative to plasma, abscess concentrations of moxifloxacin were significantly higher than of cefpirome (p = 0.0...

In pharmacokinetic studies it occurs more or less frequently that some measurements are reported to be below the limit of quantification. These data are usually discarded in estimating the terminal half-life by non-compartmental methods. We modify this approach to allow for incorporating data below the quantification limit into the analysis. This is achieved by using maximum likelihood methods ...