Src family kinases are maintained in an assembled, inactive conformation by intramolecular interactions of their SH2 and SH3 domains. Full catalytic activity requires release of these restraints as well as phosphorylation of Tyr-416 in the activation loop. In previous structures of inactive Src kinases, Tyr-416 and flanking residues are disordered. We report here four additional c-Src structure...

BACKGROUND AMG 416 is a novel peptide agonist of the calcium-sensing receptor (CaSR). This report describes the activity of AMG 416 in two different rodent models of uremia, compared in each case to cinacalcet, an approved therapeutic for secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease on dialysis. METHODS AMG 416 was administered as a single intravenous (IV) bolu...

We present new VLA C-configuration H i imaging of the Lyα-emitting starburst galaxies Tol 1924−416 and IRAS08339+6517. The effective resolution probes neutral gas structures larger than 4.7 kpc in Tol 1924−416, and larger than 8.1 kpc in IRAS08339+6517. Both systems are revealed to be tidally interacting: Tol 1924−416 with ESO338−IG04B (6.6 = 72 kpc minimum separation), and IRAS08339+6517 with ...

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OBJECTIVE To determine the professional values of Turkish nursing students, and to explore the relationships between their characteristics. METHODS The cross-sectional study participants consisted of 416 nursing students who were studying in a nursing faculty in Western Turkey. A questionnaire was used to identify socio-demographic and educational characteristics and the Nursing Professional ...