nigella sativa (n. sativa) is a spice plant which has been traditionally used for culinary and medicinal purposes. different therapeutic properties including the beneficial effects on asthma and dyspnea, digestive and gynecology disorders have been described for the seeds of n. sativa. there is evidence of the relaxant effects of this plant and some of its constituents on different types of smo...

Cymbopogon martinii (Cm.Cr) is traditionally used in south Asian communities for the management of multiple ailments including gastrointestinal, respiratory and vascular disorders and the present study was undertaken to validate these folkloric uses. The application of a methanol extract of the plant (Cm.Cr) to isolated rabbit jejunum preparation exhibited relaxation through decrease in magnitu...

AIM OF THE STUDY To provide ethnopharmacological basis for the medicinal use of Lepidium sativum seeds in indigestion and constipation. MATERIALS AND METHODS The in vivo studies were conducted in mice, while isolated tissues of mouse, guinea-pig and rabbit were suspended in tissue bath to measure isotonic contractions. RESULTS The aqueous-methanolic extract of Lepidium sativum seeds (Ls.Cr)...

AIM OF THE STUDY In this study, we investigated the crude extract of Borago officinalis leaves (Bo.Cr) for its antispasmodic, bronchodilator, vasodilator and cardio-depressant activities to rationalize some of the traditional uses. MATERIALS AND METHODS Bo.Cr was studied using different isolated tissue preparations including rabbit jejunum, trachea, aorta, and guinea-pig atria. RESULTS Bo.C...

in order to investigate the effects of dimethylamino substituent at position 2 of the dihydropyridine nucleus on activity, starting from dialkyl l ,4-dihydro-2,6-dimethyl-4- (l-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (5a-f) which their synthesis and effects as calcium channel antagonist on guinea-pig ileum has been reported previously, dialkyl l,4-dihydro-2-[2-(dimethylamino...

Valeriana hardwickii is indigenous to Pakistan, Burma and Ceylon, where it is traditionally being used as an antispasmodic and antidiarrheal, besides its culinary use as spice. The aim of this paper was to provide pharmacological validation to these medicinal uses. The crude aqueous-methanolic extract of Valeriana hardwickii rhizome (Vh.Cr) was studied on isolated rabbit jejunum and castor oil-...

Atherosclerosis is a vascular disease that occurs as result of progressive inflammatory response in blood vessels. The method inducing atherosclerosis with the rabbit animal model can be done by modifying high-fat diet which lead to hypercholesterolemia within few days inducement atheromatic lesions. This study was conducted analyze histology small intestine group rabbits fed standard and ather...

The aqueous-ethanolic extract of the Hibiscus rosasinensis aerial parts (Hr.Cr) was studied for the possible presence of spasmogenic and spasmolytic constituents to rationalize some of its traditional uses in gastrointestinal disorders. Segments of isolated rabbit jejunum and guinea-pig ileum, 2-3 cm long were mounted seprately in Tyrode’s solution and aerated with 95% oxygen in carbon dioxide....

Nociceptin/orphanin FQ (N/OFQ) and the N/OFQ peptide (NOP) receptor play important roles in regulating gastrointestinal function. To assess whether the NOP receptor is implicated in the etiopathogenesis of irritable bowel syndrome (IBS), we measured the levels of NOP receptor mRNA and protein in the jejunal and colonic tissues of healthy subjects and patients with diarrhea-predominant IBS (D-IB...

BACKGROUND Murraya paniculata is traditionally used for management of gut, air way and cardiovascular disorders. The study was conducted for provision of pharmacological rationalization for folkloric uses of Murraya paniculata in gut, air way and cardiovascular problems. METHODS Aqueous-ethanolic extract of Mp.Cr was tested using in vitro techniques on isolated tissue of rabbit (jejunum, trac...