PURPOSE There is great recent interest in the potential value of using pentoxifylline (3,7-dimethyl-1(5-oxyhexyl)-xanthine, PTX) as an inhibitor of radiation-induced late normal tissue damage. The effects of PTX on the radiobiological parameters (alpha/beta ratio, repair half time T(1/2)) of radiation myelopathy were studied in a rat model. MATERIALS AND METHODS Anesthetized Sprague-Dawley ra...

background: spinal dural avf is the most common type of spinal vascular malformation. however, presenting symptoms differ according to site of spinal involvement. this study described a case of arteriovenous malformation with paraparesis and incontinence. case presentation: diagnosis of patient was confirmed by clinical and imaging examination using magnetic resonance image and ruling out other...

BACKGROUND Although brachytherapy is one of the most effective ways to treat metastatic spinal tumor with little damage to surrounding healthy tissue, it may cause radiation myelopathy if an overdose occurs. Establishing a valuable animal model can help to find a method to overcome its complications. In the current study, we set up a banna mini-pig model to mimic percutaneous vertebroplasty wit...

To protect the spinal cord from traction myelopathy during surgical correction of deformities, it is proposed to use an extended epidural block. The developed technique was applied in 34 patients. Myelopathy, subsequently arrested with complete restoration function lower extremities, occurred one patient day after termination article presents results studying patterns distribution solutions wat...

objective: it has been suggested that the vascular endothelial growth factor (vegf) gene expression plays an important role in radiation-induced injury to the spinal cord. this study assesses the radioprotective effects of n-acetyl-5-methoxytryptamine (melatonin) through its modulation of vegf expression after localized irradiation of the cervical spinal cord. materials and methods: in this exp...

Although cervical spondylotic myelopathy is a common cause of chronic spinal cord dysfunction in humans, little is known about the molecular mechanisms underlying the progressive neural degeneration characterized by this condition. Based on animal models of cervical spondylotic myelopathy and traumatic spinal cord injury, we hypothesized that Fas-mediated apoptosis and inflammation may play an ...

OBJECT Ossification of the posterior longitudinal ligament (OPLL) can result in significant myelopathy. Surgical treatment for OPLL has been extensively documented in the literature, but less data exist on conservative management of this condition. METHODS The authors conducted a systematic review to identify all reported cases of OPLL that were conservatively managed without surgery. RESUL...