PURPOSE Treatment options in Graves' disease are clearly defined, but management practices and the perceptions of success are varied. The outcomes of treatment in large consecutive cohorts of Graves' disease have not been well characterised. The study describes the epidemiology, management strategies and medium term outcomes following anti-thyroid drug treatment, radio-iodine ablation and surge...

Trace elements often accumulate in keratin-rich tissues. Hair, nails, and horns grow steadily but once formed are metabolically inactive and provide an archive of trace element exposure when analyzed in segments. Here we demonstrate the use of laser ablation ICP-MS for the high-resolution monitoring of trace elements in the horns of seaweed-eating sheep from North Ronaldsay, which live on grass...

The determination of I in environmental samples at ultratrace levels is very difficult by ICP-MS due to a high noise caused by Xe impurities in argon plasma gas (interference of Xe), possible IH2 1 interference and an insufficient abundance ratio sensitivity of the ICP mass spectrometer for I/I isotope ratio measurement. A sensitive, powerful and fast analytical technique for iodine isotope rat...

The presentation is far from purely morphological in that many physiologic findings (natural and experimental) are cited. Radio-active iodine obviously has contributed heavily to this type of material, although there is not much said about the biochemistry of iodine-containing compounds. In general, this work will be of great interest to biologists and workers in the preclinical sciences. As to...

Thyroid function is known to be affected by many commonly used drugs of varied chemical structures. It is known that substances like sulphonamides, perchlorates, nitrates affect thyroid activity. With the introduction of radio active iodine in experimental and clinical medicine, it has been possible to study critically the effect of drugs on thyroid activity, on the ba-is of iodine uptake by th...

The presentation is far from purely morphological in that many physiologic findings (natural and experimental) are cited. Radio-active iodine obviously has contributed heavily to this type of material, although there is not much said about the biochemistry of iodine-containing compounds. In general, this work will be of great interest to biologists and workers in the preclinical sciences. As to...

  Introduction: There is a limited number of case reports published in the past decade confirming the radio-iodine presence in the tear. These observations as well as reported cases of salivary and lacrimal gland dysfunction after radioiodine therapy stimulated investigators to clarify whether lacrimal gland function can be affected post-radioiodine therapy. Hence we ...

introduction: there is a limited number of case reports published in the past decade confirming the radio-iodine presence in the tear. these observations as well as reported cases of salivary and lacrimal gland dysfunction after radioiodine therapy stimulated investigators to clarify whether lacrimal gland function can be affected post-radioiodine therapy. hence we planned a historical cohort s...