INTRODUCTION Graves disease (GD) is the most common cause of hiperthyroidism, and the most common treatment options are surgery, antithyroid drugs and radioiodine therapy. In radiodosimetric calculations to determine radioiodine dosage it is possible to use thyroid volume estimatives based on ultrasound or scintigraphy. OBJECTIVE The present study aimed to correlate these methodologies emphas...

BACKGROUND Differentiated thyroid cancers (DTC) often form metastases in neck lymph nodes, lungs and bones. Other metastases--to the brain, kidneys, skin and liver are rare. Liver metastases of DTC occur in the terminal phase of the disease and predominantly do not accumulate radioiodine. Functional (accumulating radioiodine) metastases are very rare. MATERIAL AND METHODS In an 85 year old pa...

Radioiodine therapy is the safest, simplest, least expensive and most effective method for treatment of hyperthyroidism. The method employed in this research was a systematic bibliographic review, in which only valid studies or the clinically detailed enough open-labeled studies using validated scales were used. Iodine-131 (I-131) acts by the destructive effect of short-range beta radiation on ...

There is no ideal treatment for benign multinodular goitre. Besides surgery, which is recommended for large goitres or when malignancy cannot be excluded, the non-surgical treatment options are levothyroxine therapy and radioiodine ((131)I) therapy. Conventional (131)I therapy [without recombinant human thyroid-stimulating hormone (rhTSH)] has been used for more than a decade in symptomatic non...

A 47 year old female with papillary thyroid carcinoma was referred to our department for post-treatment whole body iodine scanning. The acquired images revealed a focal zone of intense radiotracer uptake in the right lower quadrant of the abdomen. SPECT/CT fused slices showed a focal zone of the radioiodine (131I) uptake in the right colon wall. Colonoscopy revealed a pedunculated po...

Differentiated thyroid cancers are typically iodine-avid and can be effectively treated with radioiodine. In most patients, radioiodine treatment is done for ablation of residual tissue, and in these cases the focus should be on using the minimum effective dose. Adjuvant therapy can be done to reduce the risk of recurrence, but optimal patient selection and dose are unclear. Patients with advan...

Distant metastases from thyroid cancer of follicular origin are uncommon. Treatment includes levothyroxine administration at suppressive doses, focal treatment modalities with surgery, external radiation therapy and thermal ablation, and radioiodine in patients with uptake of (131)I in their metastases. Two thirds of distant metastases will become refractory to radioiodine at some point, and wh...

PURPOSE To determine whether the selective BRAF inhibitor, dabrafenib, can stimulate radioiodine uptake in BRAF V600E-mutated unresectable or metastatic iodine-refractory papillary thyroid cancer (PTC). EXPERIMENTAL DESIGN Ten patients with BRAF V600E-mutant iodine-refractory PTC were enrolled. Absence of radioiodine uptake on iodine-131 whole body scan obtained within 14 months of study entr...

Received 2/19/2010; revised 3/3/2010; accepted 3/10/2010. For correspondence and reprints contact: Wan-Yu Lin, M.D., Department of Nuclear Medicine, Taichung Veterans General Hospital. 160 Section 3, ChungGang Road, Taichung 407, Taiwan. Tel: (886)4-23741349, Fax: (886)4-23741348, E-mail: [email protected] Whole body I scan is a regular method for detecting metastatic thyroid carcinoma. Focal ...

Since all isotopes of any element have identical chemical behaviour, the radioactive isotopes of iodine are metabolised in the same way as normal iodine, and become highly concentrated in normal or over-active thyroid tissue and, in some circumstances , in thyroid cancer tissue. It may consequently be possible to destroy part or all of such tissues by the effects of the intense local beta radia...