ACE inhibitors and ARBs (angiotensin receptor blockers) have been shown to attenuate radiation injuries in animal models of lethal gamma irradiation. These two classes of drug act by curtailing the actions of angiotensin II-linked inflammatory pathways that are up-regulated during gamma radiation in organ systems such as the brain, lung, kidney, and bone marrow. ACE inhibitors inhibit ACE and a...

Microbial melanins provide a biocompatible and scalable approach for bioremediation and radioprotection technologies due to their physicochemical properties.

*Correspon Abstract – In recent years, Radioprotection, the journal of the French Radiation Protection Society (SFRP) has evolved to an international peer-reviewed journal. This evolution, together with a recent change in the editorial board of the journal, stimulated a reflexion on the aims and topics of interest for the journal. The starting point of this reflexion is an analysis by the edito...

The efficacy of cancer treatment by radiation and chemotherapeutic drugs is often limited by severe side effects that primarily affect the hematopoietic system and the epithelium of the gastrointestinal tract. Progress in understanding differences in the mechanisms involved in the responses of normal and tumor cells to genotoxic stress has led to the development of new rational approaches to se...

Radiation-induced gastrointestinal (GI) syndrome currently has no effective prophylactic or therapeutic treatment. Previous studies and our data have demonstrated the important role of p53 in acute radiation-induced GI syndrome in mice. Many cytokines, such as tumor necrosis factor-α and fibroblast growth factor (bFGF), have been found to protect against radiation-induced intestinal injury, alt...