relationship of salivary rankl and opg with periodontal disease in type 1 diabetic patients      dr. ghasemi m .,1 dr. sattari m., 2 dr. khamseh me., 3 dr. kavoli s. 4    1 associate professor, department of periodontics , school of dentistry, islamic azad university. tehran, iran .   2 associate professor, department of immunology , school of medicine, shahid beheshti university of medical sci...

Background and Aim: Increased levels of receptor activator of nuclear factor kappa-B ligand (RANKL) and RANKL/OPG (osteoprotegerin) ratio in untreated periodontitis have been presented. However, current knowledge of periodontal treatment on osteoimmunological results is scarce. This study, aims to determine the RANKL, OPG, interleukin-1 beta (β), interleukin-10 levels in gingival crevicular flu...

Bone mass loss with the subsequent development of osteopenia and osteoporosis is related to HIV infection and antiretroviral treatment, even though the mechanisms involved have not yet been elucidated. In this report analyzes the early effects of some specific protease inhibitors on OPG/RANKL yielding and cell survival in osteoblast-like HOBIT cell line. None of the compounds, tested at scalar ...

Receptor activator of nuclear factor kappa-B ligand (RANKL) is an essential mediator of osteoclast formation, function and survival. In patients with solid tumor metastasis to the bone, targeting the bone microenvironment by inhibition of RANKL using denosumab, a fully human monoclonal antibody (mAb) specific to RANKL, has been demonstrated to prevent tumor-induced osteolysis and subsequent ske...

Infection of macrophages with bacteria induces the production of pro-inflammatory cytokines including TNF-α. TNF-α directly stimulates osteoclast differentiation from bone marrow macrophages in vitro as well as indirectly via osteoblasts. Recently, it was reported that bacterial components such as LPS inhibited RANKL-induced osteoclastogenesis in early stages, but promoted osteoclast differenti...

Osteosarcoma is a common cancer type among the youth population and usually develops in growing bones. Approximately twenty percent of osteosarcoma cases show tendency to metastases patients with have low survival rate after treatment. RANK/RANKL/OPG key regulator triad bone remodeling play critical roles tumourigenesis osteosarcoma. Anti-proliferative activity gambogic acid was determined Saos...

BACKGROUND The clinical relevance of observations of serum levels of osteoprotegerin (OPG) and receptor activator of nuclear factor -κB ligand (RANKL) in juvenile idiopathic arthritis (JIA) is not clear. To elucidate the potential role of OPG and RANKL in JIA we determined serum levels of OPG and RANKL in patients with early JIA compared to healthy children, and prospectively explored changes i...

Exposure to microgravity during space flight has caused astronauts experience decreased bone density, resulting from resorption by osteoclastic activation. Activation of the nuclear factor-?B ligand (RANKL) RANKL-producing cells, a known osteoclastogenesis-promoting factor, seems be induced under microgravity. However, role cells not yet been demonstrated due lack suitable in vitro organ cultur...

Actinobacillus actinomycetemcomitans is associated with localized aggressive periodontitis, a disease characterized by rapid loss of the alveolar bone surrounding the teeth. Receptor activator of NF-kappaB Ligand (RANKL) and osteoprotegerin (OPG) are two molecules that regulate osteoclast formation and bone resorption. RANKL induces osteoclast differentiation and activation, whereas OPG blocks ...

Receptor activator of NF-κB ligand (RANKL) is essential for osteoclastogenesis. Targeting RANKL signaling pathways has been an encouraging strategy for treating lytic bone diseases such as osteoporosis and rheumatoid arthritis (RA). Sinomenine (SIN), derived from Chinese medicinal plant Sinomenioumacutum, is an active compound to treat RA, but its effect on osteoclasts has been hitherto unknown...