We propose to study the impact on the energy footprint of two advanced algorithmic strategies in the context of high performance dense linear algebra libraries: (1) mixed precision algorithms with iterative refinement allow to run at the peak performance of single precision floating-point arithmetic while achieving double precision accuracy and (2) tree reduction technique exposes more parallel...

Performance of future large-scale HPC systems will be limited by costs associated with scaling power. Some HPC centers are reaching the limits of their existent site power delivery infrastructure and are facing prohibitive upgrade costs. Others are reaching budgetary limits on their energy operating costs. Without a breakthrough in energy efficiency, the HPC industry may fail to maintain histor...

Regulation of integrins is critical for lymphocyte adhesion to endothelium and trafficking through secondary lymphoid organs. Inside-out signaling to integrins is mediated by the small GTPase Rap1. Two effectors of Rap1 regulate integrins, RapL and Rap1 interacting adaptor molecule (RIAM). Using mice conditionally deficient in both Rap1a and Rap1b and mice null for RIAM, we show that the Rap1/R...

The ability to measure the energy consumed by cloud infrastructure is a crucial step towards the development of energy efficiency policies in the cloud infrastructure. There are hardware-based and software-based methods of measuring energy usage in cloud infrastructure. However, most hardware-based energy measurement methods measure the energy consumed system-wide - including the energy lost in...

Energy, power and resilience are the major challenges that the HPC community faces in moving to larger supercomputers. Data centers worldwide consumed energy equivalent to 235 billion kWh in 2010. A significant portion of that energy and power consumption is devoted to cooling. This thesis proposes a scheme based on a combination of limiting processor temperatures using Dynamic Voltage and Freq...

The scale of scientific High Performance Computing (HPC) and High Throughput Computing (HTC) has increased significantly in recent years, and is becoming sensitive to total energy use and cost. Energy-efficiency has thus become an important concern in scientific fields such as High Energy Physics (HEP). There has been a growing interest in utilizing alternate architectures, such as low power AR...

We have systematically compared structures of multi-helical DNA-binding domains (DBDs) which have been determined by crystallography or NMR spectroscopy. All the known multi-helical DBDs are very similar. The core of these structures consists of two alpha-helices in the helix-turn-helix combination, associated with one or two other helices. The structures can be classified according to either a...