Background: Sepsis is defined as “life-threatening organ dysfunction, caused by a dysregulated host response to infection”. Neonatal sepsis the most common cause of morbidity and mortality in neonatal period. Early diagnosis difficult. Therefore, this study was conducted with objective assess diagnostic accuracy procalcitonin marker its comparison C-reactive protein. Methods: The present hospit...

Background: Neonatal sepsis is a clinical syndrome of bacteremia characterized by systemic signs and symptoms infection in the first 28 days life. Although, Positive blood culture gold standard for diagnosis neonatal septicemia, definitive results take at least 48–72 h, resulting treatment delay. Hence certain rapid diagnostic tests such as C-reactive protein, micro erythrocyte sedimentation ra...

methods in this study, 150 children diagnosed with liver disease and ascites upon admission to nemazee teaching hospital (shiraz, iran) were examined. patients were divided into spontaneous bacterial peritonitis and sterile ascetic fluid groups according to the pmn count ≥ 250/mm3 in the ascetic fluids. routine laboratory tests were conducted and quantitative c-reactive protein (crp) levels wer...

OBJECTIVES We tested the hypothesis that a C-reactive protein and ferritin-based systemic inflammation contingency table can track mortality risk in pediatric severe sepsis. DESIGN Prospective cohort study. SETTING Tertiary PICU. PATIENTS Children with 100 separate admission episodes of severe sepsis were enrolled. INTERVENTIONS Blood samples were attained on day 2 of sepsis and bi-week...

AIMS To evaluate the commonly used markers--namely IL-6, TNF alpha, IL-1 beta, C-reactive protein and E-selection for identification of late onset neonatal sepsis; to define the optimal cutoff value for each marker in preterm neonates; to assess whether these markers could assist in early discontinuation of antibiotics in non-infected cases; and to delineate the profile of these markers during ...

The production of acute phase reactants (APRs) in the liver is stimulated by increased inflammatory cytokines. Therefore, cytokines are more advantageous than APRs for early diagnosis neonatal sepsis. There a machine Latessier TM that can produce results after about 3 minutes with small amount sample 10 μL each at same time C-reactive protein (CRP), α1 acid glycoprotein (AGP), and haptoglobin (...

INTRODUCTION High-mobility group box-1 protein (HMGB1) has been known as a chromosomal protein for many years. HMGB1 has recently been shown to be a proinflammatory cytokine with a role in the immunopathogenesis of sepsis. Lipopolysaccharide-binding protein (LBP) has a central role in the innate immune response when the host is challenged by bacterial pathogens. Procalcitonin (PCT) has been sug...