The P2Y(4) receptor is selectively targeted to the apical membrane in polarized epithelial cell lines and has been shown to play a key role in intestinal chloride secretion. In this study, we delimit a 23 amino acid sequence within the P2Y(4) receptor C-tail that directs its apical targeting. Using a mutagenesis approach, we found that four hydrophobic residues near the COOH-terminal end of the...

Background: Glucose transporter (Glut), a cellular transmembrane receptor, has a key role in the metabolism of cell glucose and is also associated with various human carcinomas.Objective: In this study, we evaluated a magnetic resonance (MR) imaging contrast agent for tumor detection based on paramagnetic gadolinium oxide (Gd2O3) coated polycyclodextrin (PCD) and mod...

Background: GABAA receptor γ2 and δ subunits are thought to be responsible for synaptic and extrasynaptic targeting. Results: We demonstrate here that α2 and α6 subunits can target δ/γ2 chimeras to synaptic and extrasynaptic sites. Conclusion: The α subunits play a direct role in GABAA receptor targeting. Significance: Different subunits of GABAA receptors encode intrinsic signals to control su...

Synergistic strategies by combining nanoreactors and prodrugs hold tremendous potential in anticancer treatment. However, precise death of target cancer cells remains a significant challenge due to the absence an elaborate targeting strategy. Here, dual-targeting approach that combines action H2O2-producing folate receptor-targeted with cyclooxygenase-2 (COX-2) targeted prodrug is reported. A f...

Introduction The receptor tyrosine kinase Axl is described as a driver for migration and metastasis well resistance against molecular targeting agents radio- chemotherapy (RCT) in various tumor entities including head neck squamous cell carcinoma (HNSCC). For the latter, clinical data describing impact of its ligand Gas6 on patient outcome are sparse.

Quantum dots (QDs) are nanoparticles that have been developed for a number of biological and biomedical applications, such as drug delivery simultaneous imaging several cells. As result their unique physicochemical features, QDs shown remarkable potential in receptor-based targeting. Functionalized (f-QDs) nano-sized smart systems can deliver wide spectrum bioactive. Surface modified fluorescen...

AbstractPyrimidine nucleosides are constituents of fundamental structure of the cells. There has been considerable attentions in the chemistry of pyrimidine derivatives due to having a wide range of biological activities such as antiviral, anti-malarial agents, cytostatic, antithelemintic, antibacterial, adenosine receptor ligands, anti-cancer agents, compounds targeting delayed-type hypersensi...