نتایج جستجو برای: recurrent epithelial ovarian cancer
تعداد نتایج: 1174137 فیلتر نتایج به سال:
Ovarian cancer is a leading cause of cancer deaths among women. Effective targets to treat advanced epithelial ovarian cancer (EOC) and biomarkers to predict treatment response are still lacking because of the complexity of pathways involved in ovarian cancer progression. Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional tar...
AIMS AND BACKGROUND Radiation therapy provides a safe and effective alternative treatment option for recurrent epithelial ovarian cancer, although it has not been a treatment of choice. We evaluated the efficacy and toxicity of radiation therapy for recurrent epithelial ovarian cancer after chemotherapy according to the disease status. METHODS This was a retrospective study of 38 patients wit...
Epithelial ovarian cancer is often considered a single pathological entity, but increasing evidence suggests that it is rather a group of different neoplasms, each with unique pathological characteristics, molecular features, and clinical behaviours. This heterogeneity accounts for the different sensitivity to antineoplastic drugs and makes the treatment of ovarian tumours a challenge. For earl...
Abstract Ovarian malignancy is the seventh most frequently diagnosed cancer among women. The common type epithelial ovarian cancer. Several subtypes with distinct biological and molecular properties exist, there inconsistency in availability of access to different modalities treatment. standard first-line management combining surgery platinum-based chemotherapy. Most them are at an advanced sta...
The ovarian cancer presentations at the 2000 ASCO meeting did not yield any major paradigm shifts in the treatment of women with epithelial ovarian cancer. Emphasis at this year's meeting focused on the potential incorporation of drugs such as topotecan, oxaliplatin, doxil, and gemcitabine into the initial treatment strategies of women with advanced ovarian cancer. These studies included the in...
The standard management for previously untreated advanced-stage epithelial ovarian cancer is optimum cytoreductive surgery followed by aggressive cytotoxic chemotherapy. This approach is based on a retrospective review of a single-institution experience published more than 30 years ago and has yet to be confirmed in a prospective randomized trial. Many subsequent studies have supported the obse...
introduction : the proto-oncogene her2 plays a key role in the control of cellular proliferation. its overexpression has been reported to be associated with a poor prognosis in cancer, particularly in breast cancer. materials and methods : in the present study, serum her2 levels were investigated in patients diagnosed with epithelial ovarian cancer. serum her2 levels were detected by an elisa c...
background: ovarian cancer is the fifth leading cause of death from malignancy in women. cd4 +cd25+foxp3+ regulatory t (treg) cells are a subset of t lymphocytes with great inhibitory impact on immune response. objectives: to investigate the percentage of cd4 +cd25+foxp3+ regulatory t cells in the peripheral blood of the iranian patients with epithelial ovarian cancer compared to healthy women ...
Despite the high objective response rate (70–80%) of advanced epithelial ovarian cancer to platinum-/taxane-based chemotherapy the majority of patients treated for this condition ultimately experience recurrence of the disease process [1–3]. At the time of documented progression of the malignancy, these individuals are candidates to receive a second-line management strategy. It is well recogniz...
Epidemiologic analysis reveals that the mortality rate from ovarian cancer is continuously decreasing due to the improvement of surgery and chemotherapy. However, the prognosis of ovarian cancer patients is still unsatisfactory overall considering that only 30% of patients are alive after five years. In fact, although surgery and first-line systemic chemotherapy induces complete and partial res...
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