OBJECTIVES Thyroid antibody positivity during pregnancy has been associated with adverse outcomes including miscarriage and preterm delivery. The aim of the study is to evaluate the obstetric outcome in pregnant women with recurrent miscarriage and their response to levothyroxine (l-T4) therapy. STUDY DESIGN AND METHODS All pregnant and non-pregnant women between 21 and 35 years of age with a...

Recurrent miscarriage is a distressing problem that affects 1% of all women. This incidence is greater than that expected by chance alone, since 10–15% of all clinically recognised pregnancies end in a miscarriage and the theoretical risk of three consecutive pregnancy losses is 0.34%. Hence, only a proportion of women presenting with recurrent miscarriage will have a persistent underlying caus...

Recurrent miscarriage affect on the female reproductive health and family harmony. For a long time, the medical assessment of the recurrent miscarriage mainly focus on the female. The role of the male factors during the process of recurrent miscarriage has not been known and need further discussing. The male factors involved in the occurrence of adverse pregnancy outcomes may include: chromosom...

Recurrent miscarriage becomes a problem that affect an increasing number of couples, almost 1% of the people who want to conceive. The aim of this study is to present the role of heterochromatic regions heteromorphism and chromosomal inversions in occurrence of recurrent miscarriage. In this study were included 354 couples with recurrent miscarriage, which presented at Medical Genetic Departmen...

Recurrent miscarriage affect on the female reproductive health and family harmony. For a long time, the medical assessment of the recurrent miscarriage mainly focus on the female. The role of the male factors during the process of recurrent miscarriage has not been known and need further discussing. The male factors involved in the occurrence of adverse pregnancy outcomes may include: chromosom...

Abstract Background A vast variety of factors may cause recurrent pregnancy loss. Blood group incompatibility of parents could cause abortion. The examination of couples or twins, blood groups showed that the blood group incompatibility can affect adversely the outcome of pregnancy. Couples with blood group incompatibility are more involved in spontaneous miscarriage. Antigenes in two differe...

BACKGROUND Overweight and obese women have been shown to have an increased risk of recurrent miscarriage as well as other adverse reproductive outcomes, but it is yet unclear whether this is due to an effect on the endometrium, embryo or both. The current study employs proteomic analysis to examine for a potential endometrial defect in obese and overweight women with recurrent miscarriage. ME...

BACKGROUND SYCP3 mutations have been shown to generate an aberrant synaptonemal complex in a dominant-negative manner and to contribute to abnormal chromosomal behavior that might lead to recurrent miscarriage. We examined whether SYCP3 mutation is associated with recurrent miscarriage caused by embryonic aneuploidy. METHODS The SYCP3 657T>C mutation was examined using PCR and sequencing in 1...