Background Angiogenesis does not fully counteract myocardial ischemia in stable angina pectoris. Refractory angina pectoris, with remaining symptoms despite medication and no possibility for bypass surgery or angioplasty, is rather common. Angiogenic gene therapy is a novel treatment strategy for these patients. Methods and results In study I, six patients with refractory angina received intram...

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In the current era of widespread use of myocardial revascularization, angina has not disappeared. It is a common symptom among patients with stable coronary artery disease (affecting approximately 20% of patients) and has ominous prognostic implications in terms of subsequent risk of death and myocardial infarction. It is also associated with an increased risk of hospitalization for cardiovascu...

Despite significant advances in revascularization techniques and medical therapy, there remains a significant population of patients who continue to have intractable angina symptoms. This review aims to define the patients with refractory angina pectoris (RAP) and to present the therapeutic options currently available for this condition. RAP itself is defined and the pharmacological treatment o...

Angina pectoris, cardiac pain associated with ischemia, is considered refractory when optimal anti-anginal therapy fails to resolve symptoms. It is associated with a decreased life expectancy and diminishes the quality of life. Spinal cord stimulation (SCS) may be considered for patients who have also undergone comprehensive interventions, such as coronary artery bypass graft (CABG) and percuta...

Correspondence to: Dr Mike J L DeJongste, Department of Cardiology, Thoraxcenter, University Hospital of Groningen, PO Box 30,001, 9700 RB Groningen, The Netherlands; m.j.l.de.jongste@ thorax.azg.nl _________________________ I n contrast to the tremendous increase in practical opportunities and theoretical knowledge in the western world, resulting in a doubling of our average life expectancy, t...

Refractory coronary vasospasm subsequent to reperfusion, such as cardiopulmonary resuscitation or revascularization, for myocardial infarction may respond to fasudil in the superacute phase. Continuous low-dose fasudil administration should be an option for refractory coronary vasospastic angina (VSA).

OBJECTIVES We attempted to answer the question, Is balloon angioplasty a reasonable alternative to repeat coronary artery bypass graft surgery in patients with previous coronary bypass graft surgery, medically refractory unstable angina and vein graft lesions? BACKGROUND Patients with medically refractory unstable angina need revascularization. Patients with previous coronary artery bypass gr...