Adenosine A2A receptor (A2AR) agonists reduce invariant natural killer T (iNKT) cell activation and decrease inflammation in sickle cell disease (SCD) mice. We conducted a phase 1 trial of the A2AR agonist regadenoson in adults with SCD. The target dose was 1.44 μg/kg/h. iNKT cell activation was evaluated using antibodies targeting the p65 subunit of nuclear factor-κB (phospho-NF-κB p65), inter...

BACKGROUND Adenosine cardiovascular magnetic resonance (CMR) can accurately quantify myocardial perfusion reserve. While regadenoson is increasingly employed due to ease of use, imaging protocols have not been standardized. We sought to determine the optimal regadenoson CMR protocol for quantifying myocardial perfusion reserve index (MPRi) - more specifically, whether regadenoson stress imaging...

Background Transient ischemic dilation of the left ventricle may be suggestive of global myocardial ischemia on SPECT stress imaging. While SPECT stress/rest imaging relies on computation-adjusted volumetric data to calculate a stress/rest “TID ratio,” measured at 20 to 30 minutes after peak regadenoson stress, cardiac MRI (CMR) allows for the direct measurement of LV wall thickness and cavity ...

Methods Patients underwent regadenoson CMR that included 3 (basal, mid, apical) slices of rest and peak stress real-time cines, with matching stress and rest first-pass perfusion, and late gadolinium enhancement (LGE) imaging. The reference standard for presence or absence of CAD was derived from invasive coronary angiography or coronary CT angiography (CTA). Invasive angiography established si...

Methods Seventeen healthy normal volunteers with Framingham score less than 1% underwent vasodilator stress testing with regadenoson using a SSFP sequence. Rest imaging (Rest 1) was performed initially. Twenty minutes later, regadenoson 400mcg was administered as a 10 second injection with saline flush. Stress imaging was done 70 seconds after the injection. All volunteers received aminophyllin...

UNLABELLED Our objective was to study the diagnostic performance of regadenoson (82)Rb myocardial perfusion PET imaging to detect obstructive coronary artery disease (CAD). METHODS We studied 134 patients (mean age, 63 ± 12 y; mean body mass index, 31 ± 9 kg/m(2)) without known CAD (96 with coronary angiography and 38 with low pretest likelihood of CAD). Stress left ventricular ejection fract...

INTRODUCTION Myocardial perfusion imaging (MPI) is widely used in the evaluation of known and suspected coronary artery disease (CAD). Imaging of heart in stress and rest enables the comparison of myocardial uptake of radiotracer in proportion to the needs and coronary flow, which is used for detection of perfusion defects. Exercise stress and pharmacologic agents are used for the stressing pur...

Myocardial perfusion imaging using radionuclides is a well-established protocol for determining the diagnosis, prognosis, and management of coronary artery disease. Pharmacologic stress agents are used to induce cardiac hyperemia in patients unable to achieve the target workload by physical exercise alone. The vasodilators adenosine and dipyridamole are most commonly used, with dobutamine used ...

Background Patients with chronic obstructive pulmonary disease (COPD) often present with symptoms equivalent to an acute coronary syndrome (ACS) and slightly elevated high sensitive troponine in the observational range (hsTnT 14-53 ng/l). While this cannot differentiate between coronary or pulmonary origin of myocardial damage it necessitates further investigation since it has prognostic impact...

Background The diagnostic performance of cardiovascular magnetic resonance (CMR) utilizing adenosine for detection of myocardial ischemia is well established. However, adenosine requires continuous infusion, which is challenging in the CMR environment, and has frequent side effects. The diagnostic accuracy of stress CMR using regadenoson, a newer vasodilator agent that is administered as a sing...