Remote Direct Memory Access (RDMA) is a technology to update a remote machine’s memory without intervention at the receiver side. We evaluate where RDMA can be usefully applied and where it is a loss in Object-Oriented DSM systems. RDMA is difficult to use in modern OO-DSMs due to their support for large address spaces, advanced protocols, and heterogeneity. First, a communication pattern that ...

Following initial encoding, memories undergo a prolonged period of reorganization. While such reorganization may occur in many different memory systems, its purpose is not clear. Previously, we have shown that recall of recent contextual fear memories engages the dorsal hippocampus (dHPC). In contrast, recall of remote contextual fear memories engages a number of different cortical regions, inc...

Forgetting of recent fear memory is promoted by treatment with memantine (MEM), which increases hippocampal neurogenesis. The approaches for treatment of post-traumatic stress disorder (PTSD) using rodent models have focused on the extinction and reconsolidation of recent, but not remote, memories. Here we show that, following prolonged re-exposure to the conditioning context, enhancers of hipp...

INTRODUCTION Previous studies have demonstrated that the β-adrenergic receptor antagonist propranolol impairs fear memory reconsolidation in experimental animals. There are experimental parameters such as the age and the strength of memory that can interact with pharmacological manipulations of memory reconsolidation. In this study, we investigated the ability of the age and the strength of mem...

Shared memory applications running on NUMA machines suffer from the overhead caused by excessive remote memory accesses since references to remote memories normally exhibit a significant higher latency. Common approaches for reducing remote memory accesses are either compiler-based optimizations or OS-supporting data and/or computation

Non-volatile memory (NVM) and remote direct memory access (RDMA) provide extremely high performance in storage and network hardware. However, existing distributed file systems strictly isolate file system and network layers, and the heavy layered software designs leave high-speed hardware under-exploited. In this paper, we propose an RDMA-enabled distributed persistent memory file system, Octop...

Deficits in autobiographical memory appear earlier for recent than for remote life periods over the course of Alzheimer's disease (AD). The present study aims to further our understanding of this graded effect by investigating the cognitive and neural substrates of recent versus remote autobiographical memories in patients with amnestic Mild Cognitive Impairment (aMCI) thanks to an autobiograph...

We describe the design and implementation of FaRM, a new main memory distributed computing platform that exploits RDMA to improve both latency and throughput by an order of magnitude relative to state of the art main memory systems that use TCP/IP. FaRM exposes the memory of machines in the cluster as a shared address space. Applications can use transactions to allocate, read, write, and free o...

Recent studies have shown that the anterior (ATN) and lateral thalamic nuclei (including the intralaminar nuclei; ILN/LT) play different roles in memory processes. These nuclei have prominent direct and indirect connections with the hippocampal system and/or the prefrontal cortex and may thus participate in the time-dependent reorganization of memory traces during systems-level consolidation. W...