نتایج جستجو برای: renal protective
تعداد نتایج: 352813 فیلتر نتایج به سال:
objective(s):there are a few previously reported studies about the effect of nigella sativa oil on renal ischemia-reperfusion injury (iri). the aim of the present study was to test the hypothesis whether pre- or post-treatment with n. sativa hydroalcoholic extract (nse) would reduce tissue injury and oxidative damages in a clinically relevant rat model of renal iri. materials and methods: ir...
Background: Acetaminophen (APAP) overdose causes renal and hepatic injury. It is also believed that oxidative stress has a pivotal role in APAP-induced renal injury. Therefore, protective effects of different antioxidants have been examined in APAP-induced renal and hepatic toxicity models. Stevia rebadiana is a plant with a high degree of natural antioxidant activity in its leaf extract. T...
Background & Aims: Cadmium (Cd) is a heavy metal that has widespread use in industries and is entering the food chain in different ways, including soil and water. Magnesium (Mg) supplementation could have a protective effect against cadmium toxicity because of their antagonistic properties. In this work the influence of Mg on toxicity that is caused by Cd on serum parameters related to renal fu...
Background and Objective: Biochanin A, a bioflavonoid in red clover and soybeans, is well-known as an anti-diabetic and anti-lipidemic flavonoid. The aim of this investigation was to study the renal and hepatic effects of biochanin A in streptozocin-induced diabetic rats. Materials and Methods: Diabetes was induced in Wistar rats by administration of streptozocin (35 mg/kg of body weight) in...
Renal ischemia/reperfusion (I/R) injury continues to be a complicated situation in clinical practice. Genistein, the main isoflavone found in soy products, is known to possess a wide spectrum of biochemical and pharmacological activities. However, the protective effect of genistein on renal I/R injury has not been well investigated. In the current study, we explore whether genistein exhibits it...
Background: Regulatory T cells have been suggested to have a protective role against acute rejection in allograft recipients. However, there is little information available about their contribution to chronic rejection process. The role of transforming growth factor-beta 1 (TGF- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. Objectives: To eva...
Introduction: Renal ischemia reperfusion (I/R) caused kidney injury gender dependently. High fat diet (HFD) contributes the development of renal dysfunction. L-arginine (L-arg) and regular exercise are recognized to be protective in I/R and lipotoxicity. We compared the role of aerobic exercise and L-arg supplementation against renal I/R in male and female rats fed with HFD. Methods: 54 adult ...
We showed previously that activation of A(1) adenosine receptors (AR) protects against renal ischemia-reperfusion (IR) injury in rats and mice. In the heart, transient A(1)AR activation produces biphasic protective effects: acute protection wanes after several hours but protective effects return 24-72 h later (second window of protection). In this study, we determined whether A(1)AR activation ...
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