Diabetic kidney disease represents a considerable burden; around one-third of patients with type 2 diabetes develop chronic kidney disease. In health, the kidneys play an important role in the regulation of glucose homeostasis via glucose utilization, gluconeogenesis and glucose reabsorption. In patients with diabetes, renal glucose homeostasis is significantly altered with an increase in both ...

background: prolonged use of cyclosporine a for prevention of allograft rejection is associated with nephrotoxicity development. naringenin and olive oil are beneficial dietary antioxidants with potential renoprotective properties. this study aimed to evaluate the therapeutic effect of naringenin and olive oil in alleviating cyclosporine induced nephrotoxicity in rats by the assessment of renal...

Renin-angiotensin-aldosterone system (RAAS) blockade with angiotensin-converting enzyme inhibitors (ACE-I) or angiotensin II (Ang II), AT(1)-receptor blockers (ARB) is the cornerstone of renoprotective therapy. Still, the number of patients with end-stage renal disease is increasing worldwide, prompting the search for improved renoprotective strategies. In spite of proven efficacy at group leve...

OBJECTIVE To compare quality-of-care indicators for management of patients with chronic kidney disease (CKD) and type 2 diabetes among the James Bay Cree of Northern Quebec with those among residents of Montreal, Que. DESIGN A cross-sectional survey using medical records from patients seen between 2002 and 2008. SETTING Predialysis clinics of the McGill University Health Centre in Montreal....

Although cisplatin is the standard platinum-based anticancer drug used to treat various solid tumors, it can cause damage in normal kidney cells. Protective strategies against cisplatin-induced nephrotoxicity are, therefore, clinically important and urgently required. To address this challenge, we investigated the renoprotective effects of Hypoxylontruncatum, a ball-shaped wood-rotting fungus. ...

I read with great interest the article by Altın et al. (1) with reference to their experience on dabigatran treatment for acute renal infarction (ARI) in a case report entitled "A novel oral anticoagulant, dabigatran, in acute renal infarction” published in Anatol J Cardiol 2015; 15: 158-9. The authors claimed that in patients with ARI, a direct thrombin inhibitor, dabigatran, is preferred for ...

Erythropoietin (EPO) has traditionally been viewed as a hormone dedicated to the regulation of erythropoiesis. More recently, the EPO receptor (EPOR) has been found to be expressed in a large variety of non-haematopoietic tissues suggesting that EPO might have important actions beyond erythrocyte production. Over the last five years, short-term, high dose administration of EPO has been shown to...