objective(s):this study investigated the effects of melatonin, famotidine, mirtazapine, and thiamine pyrophosphate on ischemia/reperfusion (i/r) injury in diabetic rats and evaluated oxidant and antioxidant marker measurement results. it also examined the effects of the drugs aimed at preventing infertility that may result from i/r injury. materials and methods: diabetic rats were divided into ...

Objective(s): The aim of this study is to determine the therapeutic effects of pomegranate seed oil, which is a powerful antioxidant and anti-inflammatory agent, on ovarian-ischemia and reperfusion injury in rats.Materials and Methods: Fifty-six  female albino Wistar rats were divided into 7 equal groups. Group 1; Sham Operation, Group 2; Ischemia, Group 3; Ischemia + Reperfusion, Group 4; Isch...

Abstract Objectives Patients suffering from myocardial ischemia-reperfusion (IR) injuries usually have varying degrees of negatively-affecting comorbidities like hyperlipidemia. We evaluated the preconditioning effect ginsenoside-Mc1 on reperfusion injury-induced arrhythmias, along with cardiac oxidative stress, endoplasmic reticulum stress protein expression, and histological damage in hyperli...

background: testicular torsion and detorsion causes reperfusion injury which damages the testicular tissue and affects the quality of sperm. deterioration in the quality of sperm worldwide is the recent scenario and one of its reasons is testicular ischemic/ reperfusion (ir) injury. therefore the present study aims at producing new drugs for the treatment of testicular ir injury. methods: 42 an...

Objective(s):Acute kidney injury (AKI), a syndrome characterized by decreased glomerular filtration, occurs in every 1 of 5 hospitalized patients.  Renal ischemia-reperfusion, one of the main causes of AKI, is of particular importance in the setting of kidney transplantation. Materials and Methods: Sixty male rats were divided into four groups including control, nephrectomy, sham surgery and re...

Many complicated mechanisms are involved in brain ischemia and the role of inflammatory factors in the progression of post-ischemic injury is inevitable. In present study, anti-inflammatory effect of berberine has been investigated in reperfusion injury after acute ischemic stroke. Male Wistar rats weighing 250-270 gr were randomly divided into four cohorts: healthy rats (control, n=20), sham-o...

objective(s):there are a few previously reported studies about the effect of nigella sativa oil on renal ischemia-reperfusion injury (iri). the aim of the present study was to test the hypothesis whether pre- or post-treatment with n. sativa hydroalcoholic extract (nse) would reduce tissue injury and oxidative damages in a clinically relevant rat model of renal iri.    materials and methods: ir...

Ovarian torsion is one of the gynecological emergencies that affect ovarian tissue integrity and fertility. In this study, we aim to investigate effects Momordica charantia (MC) on injury induced by ischemia-reperfusion. Twenty-four rats were assigned three groups: control group, ischemia-reperfusion (I/R) group IR + MC group. 600 mg/kg extract given via orogastric route. 3-hour ischemia reperf...

The present study aimed to evaluate the protective effect of gallic acid on gastric mucosal lesions caused by ischemia-reperfusion (I/R) injury in rat. Forty male rats were randomly divided into sham, control (I/R injury) and three gallic acid-pretreated groups. To induce I/R lesions, the celiac artery was clamped for 30 min and then the clamp was removed to allow reperfusion for 6 hr. Pretreat...