Background: Haplotyping is invaluable not only to identify genetic variants underlying a disease or trait, but also to study evolution and population history as well as meiotic and mitotic recombination processes. Current genome-wide haplotyping methods rely on genomic DNA that is extracted from a large number of cells. Thus far random allele drop out and preferential amplification artifacts of...

Many endangered captive populations exhibit reduced genetic diversity resulting in health issues that impact reproductive fitness and quality of life. Numerous cost effective genomic sequencing and genotyping technologies provide unparalleled opportunity for incorporating genomics knowledge in management of endangered species. Genomic data, such as sequence data, transcriptome data, and genotyp...

CAVEOLAE-DEPENDENT ENDOCYTOSIS IS REQUIRED FOR CLASS A MACROPHAGE SCAVENGER RECEPTOR-MEDIATED APOPTOSIS IN MACROPHAGES Xu-Dong Zhu, Yan Zhuang, Jing-Jing Ben, Ling-Ling Qian 2 , Han-Peng Huang , Hui Bai, Jia-Hao Sha, Zhi-Gang He 1,2 and Qi Chen From the Institute of Reproductive Medicine and Atherosclerosis Research Centre, Key Laboratory of Human Functional Genomics, Nanjing Medical University...

The recent release of the Populus trichocarpa genome sequence will dramatically enhance the efficiency of functional and comparative genomics research in trees . This provides researchers studying various developmental processes related to the perennial and tree life strategies with a completely new set of tools. Intimately associated with the life strategy of trees are their abilities to maint...

listeria monocytogenes can cause serious infection and recently, relapse of listeriosis has been reported in leukemia and colorectal cancer, and the patients with klebsiella pneumoniae are at increased risk of colorectal cancer. translation initiation codon recognition is basically mediated by shine-dalgarno (sd) and the anti-sd sequences at the small ribosomal rna (ssu rrna). in this research,...

saffron is one of the highly exotic spices known for traditional values and antiquity. it is used for home décor besides serving as a colorant flavor and is widely known for medicinal value. over the last few years, saffron has garnered a lot of interest due to its anti-cancer, anti-mutagenic, anti-oxidant and immunomodulatory properties. integration of systems biology approaches with wide appl...

Chemicals released into the environment potentially disrupt the endocrine system in wild animals and humans. Developing organisms are particularly sensitive to estrogenic chemicals. Exposure to estrogens or estrogenic chemicals during critical periods of development induces persistent changes in both reproductive and nonreproductive organs, including persistent molecular alterations. Estrogen-r...

stem cell factor (scf) is a critical protein with key roles in the cell such as hematopoiesis, gametogenesis and melanogenesis. in the present study a comparative analysis on nucleotide sequences of scf was performed in humanoids using bioinformatics tools including ncbi-blast, mega6, and jbrowse. our analysis of nucleotide sequences to find closely evolved organisms with high similarity by ncb...

personalized medicine is significantly changing the fundamentals of healthcare. genetic diagnostic tests are used in various parts of medicine – from initial screening to the diagnosis and finally treatment. investigations in fields of drug development indicate that oncology may lead other therapeutic areas in the number of targeted therapies on the marketplace as well as in the pipeline, expec...