Introduction: The strains of Pseudomonas aeruginosa are known as an opportunistic pathogen that can cause infections in humans and animals. Metallo-β-lactamases (MBLs) are the most significant factors of resistance to carbapenem antibiotics in these bacteria. This study was designed to identify the MBLs producing P. aeruginosa isolates in three hospitals of Tehran, Iran. Methods: Tota...

conclusions the high rate of mdrpa and its ability to produce biofilm is an alarm for public health. the statistical analysis showed that biofilm production in the mdrpa isolates was significantly higher than that in the non–mdrpa isolates (p < 0.001). background pseudomonas aeruginosa possesses a variety of virulence factors and infections caused by multidrug-resistant p. aeruginosa (mdrpa) in...

conclusions this study was the first report of the emergence of the plasmid-encoded blaoxa genes among e. cloacae isolates in iran. these findings highlight the need to use appropriate infection control policy and rational antibiotic therapy to reduce further spread of these resistant bacteria in the studied hospitals. results in total, 48 esbl-producing isolates (58.5%) were positive for the b...

conclusions ctx-m was the most prevalent esbl genotype in uropathogenic e. coli (upec) isolated from uti. in addition, a high frequency of qnr genes among esbl-producing e. coli was identified in this study. in order to avoid treatment failures, we recommend using phenotypic and molecular methods to diagnose these enzymes and qnr genes. results the highest sensitivity was seen to imipenem (96.7...

Background: A routine phenotypic test has not been recommended for detection of metallo-β-lactamases (MBLs) producing Enterobacteriaceae species such as Escherichia coli. The current study was conducted to compare the 2-Mercaptopropionic acid (2-MPA) phenotypic method and ertapenem non-susceptibility test with polymerase chain reaction in predicting the production of MBLs in clinical isolates o...

conclusions the results of this study phenotypically and genotypically confirmed the high frequency of esbl-producing strains, such as the ctx-m and ctx-m-1 genes, among enterobacteriaceae isolates in our region. therefore, use of antibiotic susceptibility testing for the detection of esbl isolates prior to the prescription of beta-lactam antibiotics is recommended. this could help prevent the ...

Current study was conducted to determine prevalence and antimicrobial susceptibility patterns, ESBL, AmpC and carbapenemase- producers among clinical isolates of Enterobacteriaceae. Three hundred and seven non-duplicative clinical isolates were collected from hospitalized patients in five medical centers in Azerbaijan, Iran. Initial screening for β-lactamase production was performed using disc ...

introduction: extended spectrum beta-lactamase (esbl) producing escherichia coli generate a major problem for clinical therapeutics and epidemiological study. the incidence of esbl producing strains among clinical isolates has been steadily increasing during the past few years, and remains an important cause of failure of therapy with cephalosporins. the aim of this study was to determine the a...