The regulation of dopamine and serotonin synthesis in rat brain striatal synaptosomes has been studied using HPLC methods. Noradrenaline was shown to markedly inhibit both the synthesis of dopamine and serotonin. The response of the synaptosomes to the concentrations of noradrenaline appeared to be biphasic, a very effective inhibition occurring at low concentrations (1-5 µm) and a relativ...

The ability to prevent unwanted movement is fundamental to human behavior. When healthy adults must prevent a subset of prepared actions, execution of the remaining response is markedly delayed. We hypothesized that the delay may be sensitive to the degree of similarity between the prevented and continued actions. Fifteen healthy participants performed an anticipatory response inhibition task t...

The ethanolic extract of Wedelia chinensis (EEWC) belonging to the family of Asteraceae was evaluated by hot plate and acetic acid induced writhing methods to assess its analgesic activity. The extract was also evaluated for its by using on carrageenan, mediators such as histamine and serotonin induced paw oedema, and cotton pellet induced granuloma tests for its effect on acute and chronic ...

introduction: in the present study the effect of nucleus basalis of meynert (nbm) destruction on the temporal characteristics of response integration evoked by multiple whisker stimulations in rat barrel cortex was studied. material and methods: wistar male rats weighing 250-350 g were used. the animals were randomly distributed into two groups: in the first group bilateral nbm lesions was indu...

The ethanolic extract of Wedelia chinensis (EEWC) belonging to the family of Asteraceae was evaluated by hot plate and acetic acid induced writhing methods to assess its analgesic activity. The extract was also evaluated for its by using on carrageenan, mediators such as histamine and serotonin induced paw oedema, and cotton pellet induced granuloma tests for its effect on acute and chronic ...

Ketotifen is a benzocycloheptathiophene with a range of pharmacological activities. The present study was carried out to evaluate the action of ketotifen on isolated rat bladder contractions induced by KCI and acetylcholine, compared with the effects of other drugs. Ketotifen (5 µM) reduced the response to acetylcholine on rat isolated bladder without altering the maximum response and shift...