OBJECTIVE To determine functional connectivity of the default mode network in patients with sensorineural hearing loss (SNHL) in resting state. METHODS The posterior cingulate cortex was selected as a seed for assessment of functional connectivity of the activated brain areas in resting state by using a seed-based correlation analysis of the resting state functional magnetic resonance imaging...

Resting state-functional magnetic resonance imaging (RS-FMRI) is a neuroimaging technique that allows repeated assessments of functional connectivity in resting state. While task-related FMRI is limited to indirectly measured drug effects in areas affected by the task, resting state can show direct CNS effects across all brain networks. Hence, RS-FMRI could be an objective measure for compounds...

Ongoing debate exists within the resting-state functional MRI (fMRI) literature over how intrinsic connectivity is altered in the autistic brain, with reports of general over-connectivity, under-connectivity, and/or a combination of both. Classifying autism using brain connectivity is complicated by the heterogeneous nature of the condition, allowing for the possibility of widely variable conne...

This paper considers the identification of large directed graphs for resting-state brain networks based on biophysical models of distributed neuronal activity, that is, effective connectivity. This identification can be contrasted with functional connectivity methods based on symmetric correlations that are ubiquitous in resting-state functional MRI (fMRI). We use spectral dynamic causal modeli...

INTRODUCTION Resting-state functional MRI (rs-fMRI) of the brain has been successfully used to identify altered functional connectivity in the motor network in multiple sclerosis (MS). In clinically stable patients with MS, we recently demonstrated increased coupling between the basal ganglia and the motor network. Accordingly, rs-fMRI in MS is particularly suited to investigate functional reor...

INTRODUCTION Resting-state functional MRI (rs-fMRI) of the brain has been successfully used to identify altered functional connectivity in the motor network in multiple sclerosis (MS). In clinically stable patients with MS, we recently demonstrated increased coupling between the basal ganglia and the motor network. Accordingly, rs-fMRI in MS is particularly suited to investigate functional reor...

Functional near-infrared spectroscopy (fNIRS) is an emerging low-cost noninvasive neuroimaging technique that measures cortical bloodflow. While fNIRS has gained interest as a potential alternative to fMRI for use with clinical and pediatric populations, it remains unclear whether fNIRS has the necessary sensitivity to serve as a replacement for fMRI. The present study set out to examine whethe...

Objective: To longitudinally evaluate fMRI whole-brain resting-state functional connectivity changes in relation to cognitive decline in Parkinson’s disease (PD). Methods: Resting-state fMRI scans were acquired in 55 PD patients (mean age 65.8 years, SD 6.37; average disease duration 9.24 years, SD 3.96) and 15 matched controls (mean age 64.4 years, SD 8.65). We performed overall (i.e. one whol...

The brain is a dynamic, flexible network that continuously reconfigures. However, the neural underpinnings of how state-dependent variability of dynamic functional connectivity (vdFC) relates to cognitive flexibility are unclear. We therefore investigated flexible functional connectivity during resting-state and task-state functional magnetic resonance imaging (rs-fMRI and t-fMRI, resp.) and pe...

Anti-epileptic drugs (AEDs) have a global effect on the neurophysiology of the brain which is most likely reflected in functional brain activity recorded with EEG and fMRI. These effects may cause substantial inter-subject variability in studies where EEG correlated functional MRI (EEG-fMRI) is used to determine the epileptogenic zone in patients who are candidate for epilepsy surgery. In the p...