BACKGROUND Compromised iron status is important in restless legs syndrome pathophysiology. We compared the efficacy and tolerability of ferric carboxymaltose (single intravenous dose) versus placebo for restless legs syndrome treatment in iron-deficient nonanemic patients. METHODS Patients with moderate to severe restless legs syndrome and serum ferritin < 75 μg/L (or serum ferritin 75-300 μg...

Data collected from medical literature indicate that dopaminergic agonists alleviate Restless Legs Syndrome symptoms while dopaminergic agonists antagonists aggravate them. Dopaminergic agonists is a physiological regulator of thyroid-stimulating hormone. Dopaminergic agonists infusion diminishes the levels of thyroid hormones, which have the ability to provoke restlessness, hyperkinetic states...

Aims: The chronic renal failure and the subsequent hemodialysis and its consequent problems such as restless legs syndrome affect the individual’s quality of life through the changes they cause in his life style and health status. The present study was conducted to investigate the association between the quality of life and restless legs syndrome in hemodialysis patients. Materials and Methods:...

BACKGROUND The restless legs syndrome is a sensorimotor disorder that is very common in patients on hemodialysis. Due to pharmacological treatments which have their own side effects, nowadays, studies have turned to non-pharmacological treatments. OBJECTIVES The present study aims to assess the effect of stretching exercises on the severity of restless legs syndrome in patients on hemodialysi...

restless leg syndrome (rls) is a common cause of painful legs. the leg pain of restless leg syndrome typically eases with motion of the legs and becomes more noticeable at rest. stress or emotional upset can make symptoms worse. the purpose of the present study was to examine the relationship of emotional disturbance and quality of life to the severity of rls. using a descriptive-correlational ...

background: restless legs syndrome (rls) is a common movement disorder. the occurrence of this syndrome is due to genetic factors and lifestyle. this study performed to determine restless legs syndrome (rls) prevalence in iranian multiple sclerosis (ms) patients and the possible risk factors. methods: this cross‑sectional study was conducted with ms patients, and the age‑ and sex‑matched contro...

conclusions the most important factor in diagnosis is physician’s attention and clinical experience with this condition and using irlssg. results two major theories are developed regarding the pathophysiology of rls. the first one concerns central nervous system dopamine imbalance and the second one concerns intracellular iron dysregulation. the most common used pharmacologic agents in treatmen...